False-positive urine pregnancy screening tests (UPST) have been reported among patients with bowel-containing urinary reconstruction (BCUR). However, the true frequency of such inaccurate results, which have been attributed to urinary mucous or other proteins interfering with or mimicking the binding of beta-HCG in the assay, is unknown in this population. We sought to determine the incidence of false-positive pregnancy screening tests among this patient population at our institution.
Materials and methods
Using existing databases of patients with spina bifida, bladder exstrophy, and genitourinary rhabdomyosarcoma, we identified female patients with BCUR who had UPST over a 10-year period as screening prior to procedures or imaging. Patient and test result information was recorded.
A total of 120 patients with a history of BCUR were identified: 33 with spina bifida, 73 within the exstrophy-epispadias complex (EEC), and 14 with genitourinary rhabdomyosarcoma. Of this group, 46 patients (38%) had at least one UPST during the study period; 15 had 1 UPST, 6 had 2 UPSTs, 4 had 3 UPSTs, and 21 had greater than 3 UPSTs, for a total of 244 UPST in this cohort. UPSTs used at our institution included Sure-Vue brand and Alere brand (HCG sensitivity 20 mIU/ml). Types of BCUR included ileal enterocystoplasty in 25 patients, colon enterocystoplasty in 6, stomach enterocystoplasty in 5, composite enterocystoplasty in 7, and continent catheterizable channel alone (e.g. Yang-Monti, appendicovesicostomy) in 3 patients. Of the 244 UPSTs in patients with BCUR, zero (0%) were positive.
Tabled 1Summary Table Characteristics and results of urine pregnancy screening tests (UPST) in a hospital setting, among female patients with bowel-containing urinary reconstruction (BCUR), over a 10-year period.
|Spina Bifida (n = 16)||Exstrophy Complex (n = 29)||GU RMS (n = 1)||Total (n = 46)|
|Age at BCUR Repair (years, median, IQR)||13.5 (8.5–25)||4 (1.5–9.5)||2||8 (2–14.25)|
|Type of BCUR (%)|
|Augment, ileum||11 (69)||14 (48)||0||25 (54)|
|Augment, colon||5 (31)||0||1 (100)||6 (13)|
|Augment, stomach||0||5 (17)||0||5 (11)|
| Augment, compound
|0||7 (24)||0||7 (15)|
|Continent Channel only||0||3 (10)||0||3 (7)|
|Time from BCUR to first UPST (months, median, IQR)||14.5 (4–31)||139 (77.5–202.5)||147||54 (13–149.25)|
|Number of UPST per patient (%)|
|One||6 (38)||9 (31)||0||15 (33)|
|Two||2 (13)||4 (14)||0||6 (13)|
|Three||1 (6)||3 (10)||0||4 (9)|
|Greater than Three||7 (44)||13 (45)||1 (100)||21 (46)|
|Total Positive UPST||0||0||0||0|
a stomach/ileum (4), colon/ileum (1), colon/stomach (1), other (1).
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Pediatric Urology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The evolution of bladder augmentation: from creating a reservoir to reconstituting an organ.Front Pediatr. 2014; 2: 10
- False-positive pregnancy tests following enterocystoplasty.BJOG. 2012; 119: 366
- False-positive pregnancy tests in patients with enterocystoplasties.BJU Int. 2001; 87: 780
- Bladder augmentation: review of the literature and recent advances.Indian J Urol. 2007; 23: 452
- Evalynn vasquez: false positive pregnancy tests among pediatric patients with augmentation enterocystoplasties.J Urol. 2022; 207: e157
- False-positive pregnancy test secondary to ectopic expression of human chorionic gonadotropin by a gastrointestinal stromal tumor.J Surg Oncol. 2020; 122: 809-812
- False-positive urine pregnancy test in a woman with adenomysosis.Am J Emerg Med. 2009; 27: 1019 e5
- Lung carcinoma presenting with pathologic femur fracture and false-positive pregnancy test result.Ann Emerg Med. 2012; 60: 378
- Escitalopram-induced amenorrhea and false positive urine pregnancy test.Korean J Fam Med. 2017; 38: 40
- False positive urinary pregnancy test in the nephrotic syndrome.N Engl J Med. 1989; 321: 1416
Published online: February 05, 2023
Accepted: February 1, 2023
Received in revised form: January 9, 2023
Received: October 27, 2022
Publication stageIn Press Journal Pre-Proof
© 2023 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.