Epidemiologic studies have identified an increased risk of certain malignancies among
people with cystic fibrosis. Testicular cancer is one of these malignancies. Potential
explanations for this observation include primary effects of the cystic fibrosis transmembrane
conductance regulator gene or protein on tissue versus secondary effects which are
caused by abnormal anatomy and physiology. Two cases of testicular cancer among adolescent
boys receiving care at the same cystic fibrosis care center are presented. Current
U.S. Preventive Services Task Force guidelines recommend against routinely screening,
medical or self-examination, for testicular cancer among adolescent or adult males.
Given the increased risk of testicular cancer among boys and men with cystic fibrosis,
this recommendation must be reassessed. As part of its recent focus on reproductive
health, the cystic fibrosis care community should, at minimum, develop age-appropriate
education resources for adolescent and adult males with cystic fibrosis.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric UrologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- A cohort study of cystic fibrosis and malignancy.Br J Cancer. 1993 Nov; 68 (PMID: 8217592; PMCID: PMC1968740): 1025-1028https://doi.org/10.1038/bjc.1993.474
- The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group.N Engl J Med. 1995 Feb 23; 332 (PMID: 7830730): 494-499https://doi.org/10.1056/NEJM199502233320803
- Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States.J Natl Cancer Inst. 2013 Jan 16; 105 (Epub 2012 Nov 24. PMID: 23178438): 122-129https://doi.org/10.1093/jnci/djs481
- Testicular cancer in men with cystic fibrosis.J Cyst Fibros. 2022 Sep; 21 (Epub 2022 Feb 25. PMID: 35221249): 891-892https://doi.org/10.1016/j.jcf.2022.02.008
- A systematic review and meta-analysis of male infertility and the subsequent risk of cancer.Front Oncol. 2021 Oct 14; 11 (PMID: 34722244; PMCID: PMC8551623)696702https://doi.org/10.3389/fonc.2021.696702
- Screening for testicular cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement.Ann Intern Med. 2011 Apr 5; 154 (PMID: 21464350): 483-486https://doi.org/10.7326/0003-4819-154-7-201104050-00006
- USPSTF testicular examination nomination-self-examinations and examinations in a clinical setting.Am J Men's Health. 2018 Sep; 12 (Epub 2018 May 2. PMID: 29717912; PMCID: PMC6142159): 1510-1516https://doi.org/10.1177/1557988318768597
Article info
Publication history
Published online: January 18, 2023
Accepted:
January 14,
2023
Received in revised form:
December 29,
2022
Received:
December 8,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
