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Effect of topical estrogen cream compared with observation in prepubertal girls with labial adhesions

  • Author Footnotes
    1 Sung Woo Kim and Ji Yeon Han contributed equally as the first authors of this study.
    Sung Woo Kim
    Footnotes
    1 Sung Woo Kim and Ji Yeon Han contributed equally as the first authors of this study.
    Affiliations
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea

    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Search for articles by this author
  • Author Footnotes
    1 Sung Woo Kim and Ji Yeon Han contributed equally as the first authors of this study.
    Ji Yeon Han
    Footnotes
    1 Sung Woo Kim and Ji Yeon Han contributed equally as the first authors of this study.
    Affiliations
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea

    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Search for articles by this author
  • Soo Jin Han
    Affiliations
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea
    Search for articles by this author
  • Hoon Kim
    Affiliations
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea

    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Search for articles by this author
  • Seung-Yup Ku
    Correspondence
    Corresponding author: Department of Obstetrics and Gynecology, Seoul National University College of Medicine Seoul, 110-744, Korea. Tel: 82-2-2072-1971 Fax: 82-2-762-3599
    Affiliations
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea

    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Search for articles by this author
  • Author Footnotes
    1 Sung Woo Kim and Ji Yeon Han contributed equally as the first authors of this study.
Published:January 12, 2023DOI:https://doi.org/10.1016/j.jpurol.2023.01.006

      Summary

      Background

      Topical estrogen treatment has been considered the first-line treatment of labial adhesions in prepubertal girls. However, the effect of topical estrogen cream is different according to studies, and no study compared estrogen cream to observation. Objective: This study aims to investigate the efficacy of topical estrogen cream treatment compared with observation in prepubertal girls with labial adhesions.

      Study design

      The medical records of prepubertal girls diagnosed with labial adhesions from April 2005 to June 2019 were retrospectively analyzed. Baseline characteristics such as age at diagnosis and initial symptoms were collected. The primary outcome was the resolution of labial adhesion. Secondary outcomes were recurrence and side effects.

      Results

      A total of 114 patients were enrolled and divided into two groups, topical estrogen cream (n=94), and observation (n=20). Girls who were treated with estrogen cream had older age (24.6±19.0 vs. 16.7±15.3 months, p=0.037) and higher resolution rate than the observation group (100.0% vs. 85.0%, respectively, p=0.005). Girls younger than 23.3 months showed a significantly higher resolution rate to topical estrogen treatment (100% vs. 86.7%, p=0.043). Side effects and recurrences occurred exclusively in children treated with topical estrogen therapy without significant differences compared to the observation group.

      Conclusion

      Topical estrogen therapy showed a higher resolution rate than observation for the treatment of prepubertal girls with labial adhesions, especially in younger girls.

      Keywords

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