Summary
Background
Fertility Preservation (FP) for children and adolescents with cancer is underutilized.
In prepubertal individuals, ovarian and testicular tissue can be frozen; however,
this is still considered largely experimental. Our objective was to identify trends
of FP in prepubertal individuals.
Methods
We performed a retrospective study of prepubertal children with cancer identified
through the Pediatric Health Information System from 2011 to 2020. Children who underwent
a testicular or ovarian biopsy were included. Any patients with testicular or ovarian
malignancy, or other diagnoses which may have required a gonadal biopsy were excluded.
Results
A total of 418 boys under 13 and 333 girls under 12 who underwent a gonadal biopsy
were identified. There was a total of 66,929 new cancer diagnoses in girls and 86,001
new cancer diagnoses in boys during this time. The most common cancer diagnosis was
hematologic in both boys (50.96%) and girls (36.64%). A concurrent procedure at time
of gonadal biopsy was performed in 84% of boys and 62% of girls, with line insertion
being the most common. The only predictive variable of receiving a gonadal biopsy
was increasing year. Overall, only 0.04% of children had a gonadal biopsy for FP during
this time period.
Conclusions
Graphical AbstractIncidence of gonadal biopsies per year amongst prepubertal individuals.
Keywords
Abbreviations:
FP (fertility preservation), PHIS (pediatric health information systems), US (United States)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 15, 2022
Accepted:
September 13,
2022
Received in revised form:
August 23,
2022
Received:
May 30,
2022
Identification
Copyright
© 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
