Summary
Purpose
Our primary aim was to determine the prevalence of positive over-the-counter (OTC)
pregnancy tests among pediatric female and male patients who had undergone augmentation
enterocystoplasty. A secondary aim was to determine whether patient factors or urinalysis
(UA) results were associated with false positive OTC pregnancy test results in patients
with a history of augmentation enterocystoplasty.
Methods
Patients at a tertiary pediatric hospital who had previously undergone augmentation
enterocystoplasty, Mitrofanoff appendicovesicostomy only, and age- and sex-matched
controls were prospectively recruited. Urine samples were obtained, and two OTC pregnancy
tests were conducted – OTC Test A reported the ability to detect pregnancy at hCG
levels as low as 9.6 mIU/mL, while OTC Test B reported positive pregnancy test results
at hCG levels ≥25 mIU/mL. A point of care (POC) pregnancy test and UA were also completed.
Mann–Whitney U tests and Fisher's exact tests were used to assess whether patient
factors or UA results were associated with false positive pregnancy test results.
Results
Fifty pediatric patients were enrolled, including 20 with augmentation enterocystoplasty,
20 age- and sex-matched controls, and 10 with Mitrofanoff appendicovesicostomy only.
Among the 20 patients who had undergone augmentation cystoplasty, 15 (75.0%) had positive
pregnancy test results on OTC Test A, including 11/13 (84.6%) females and 4/7 (57.1%)
males. No control patients or patients with Mitrofanoff appendicovesicostomy only
had a positive test. No patients had positive pregnancy test results on OTC Test B
or the POC test. While patients with augmentation enterocystoplasty were significantly
more likely to test positive for blood (p = 0.01), nitrate (p = 0.03), and leukocytes
(p < 0.0001), these factors were not significantly associated with false positive
pregnancy results. No patient factors or UA results were associated with increased
likelihood of false positive OTC pregnancy test results.
Conclusions
Graphical AbstractPatient Characteristics and Over-the-Counter Pregnancy Test Results among 20 Patients
with Bladder Augmentation, 20 Controls, and 10 Patients with Mitrofanoff Appendicovesicostomy
only.
Keywords
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Article info
Publication history
Published online: September 13, 2022
Accepted:
September 12,
2022
Received:
July 7,
2022
Identification
Copyright
© 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
