Children with complex medical conditions pose many difficulties in the evaluation
and prevention of their nephrolithiasis episodes. DeFoor et al. present the next logical
step in understanding the etiology of urinary stone disease in these children. The
authors investigated the 24-h urine analyses of children with complex chronic conditions,
many of whom depend upon enteral nutrition, and compared these to an unmatched cohort
of otherwise healthy children with nephrolithiasis. While such an analysis is limited
due to the retrospective and uncontrolled nature of the assessments, the difficulty
in obtaining urine samples in such a population makes this study a valuable manuscript
for future reference. Interestingly, as opposed to common hypotheses related to calcium
metabolism in the chronically immobilized, the authors found a significantly higher
concentration of urinary oxalate in the study population. Several possibilities could
exist to explain these differences. Oxalate is known to vary more substantially in
younger populations and perhaps repeat 24-h studies would yield different results
[
[1]
]. However, supposing these findings represent true and meaningful differences in
urinary oxalate, a consideration of oxalate metabolism is warranted.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric UrologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Analyte variations in consecutive 24-hour urine collections in children.J Pediatr Urol. 2017; 13 (632 e1- e7)
- Oxalate content of enteral nutrition formulas.J Pediatr Gastroenterol Nutr. 2019; 69: e135-e140
- Perturbations of the gut microbiome and metabolome in children with calcium oxalate kidney stone disease.J Am Soc Nephrol. 2020; 31: 1358-1369
- Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.Cell Host Microbe. 2021; 29: 394-407 e5
Article info
Publication history
Published online: July 06, 2022
Accepted:
June 24,
2022
Received:
June 24,
2022
Identification
Copyright
© 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Enteral nutrition and the risk of nephrolithiasis in complex pediatric patientsJournal of Pediatric UrologyVol. 18Issue 6
