Summary
Introduction
Tissue glue has been examined extensively for its effectiveness in pediatrics, and
the findings are good. The purpose of this research was to examine the effectiveness
of tissue glue compared to absorbable sutures for wound approximation in pediatric
circumcision.
Methods
A systematic review and meta-analysis on children who had circumcision using tissue
glue and absorbable suture were done in line with the PRISMA criteria. RevMan 5.4
was used to perform the meta-analysis. The mean differences for continuous and dichotomous
data are determined using inverse variance, and the odds ratio is calculated using
the Mantel-Haenszel technique.
Results
The inclusion criteria were met by six trials containing a total of 817 patients.
According to the analysis, tissue glue significantly reduces the duration of the operation
(MD – 7.98; 95% CI -12.35, -3.62; p = 0.0003), pain severity (SMD -0.57; 95%CI -0.80,
-0.32; p < 0.00001) and the duration of pain (MD - 2.33; 95% CI -2.57, -2.08; p < 0.00001)
compared to absorbable suture. However, we found that there was no significant difference
in the incidence of postoperative bleeding, infection, dehiscence, or overall complication
when comparing tissue glue to traditional suture.
Conclusion
Our systematic review and meta-analysis using the most recent data suggest that tissue
glue usage might reduce the operation time, as well as the intensity and duration
of postoperative pain.
Keywords
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References
- Rates of adverse events associated with male circumcision in US medical settings, 2001 to 2010.JAMA Pediatr. 2014; 168: 625-634https://doi.org/10.1001/jamapediatrics.2013.5414
- The role of 2-octyl cyanoacrylate in prevention of penile adhesions after circumcision: a prospective, randomized trial.J Pediatr Surg. 2017; 52: 1886-1890https://doi.org/10.1016/j.jpedsurg.2017.08.052
- Complications of circumcision in male neonates, infants and children: a systematic review.BMC Urol. 2010; 10: 1-13
- The use of tissue glue for circumcision in children: systematic review and meta-analysis.Urology. 2018; 115: 21-28https://doi.org/10.1016/j.urology.2018.01.022
- Minor wound repair with tissue adhesives (cyanoacrylates).UpToDate, 2019
- Paediatric sutureless circumcision-an alternative to the standard technique.Pediatr Surg Int. 2012; 28: 305-308https://doi.org/10.1007/s00383-011-3015-0
- The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.Bmj. 2021; : 372
- The efficacy of tissue glue in pediatric circumcision wound approximation: a meta-analysis of randomized controlled trial protocol.Open Sci Framew. 2022; https://doi.org/10.17605/OSF.IO/5743S
- Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range.BMC Med Res Methodol. 2014; 14: 135https://doi.org/10.1186/1471-2288-14-135
- Meta-analysis in clinical trials.Contr Clin Trials. 1986; 7: 177-188https://doi.org/10.1016/0197-2456(86)90046-2
- A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints.Stat Med. 2006; 25: 3443-3457
- Circumcision with Glubran® 2 in children: experience of Italian center.Gland Surg. 2016; 5: 391
- Sutureless versus interrupted sutures techniques for neonatal circumcision; a randomized clinical trial.J Pediatr Urol. 2020; 16 (493-e1)
- A prospective randomized study of wound approximation with tissue glue in circumcision in children.J Paediatr Child Health. 1997; 33: 515-516https://doi.org/10.1111/j.1440-1754.1997.tb01661.x
- The advantages of cyanoacrylate wound closure in circumcision.Pediatr Surg Int. 2011; 27: 879-883https://doi.org/10.1007/s00383-010-2741-z
- Wound approximation with tissue glue in circumcision.Int J Urol. 2005; 12: 374-377https://doi.org/10.1111/j.1442-2042.2005.01027.x
- Sutureless circumcision: a prospective randomised controlled study.Pediatr Surg Int. 2004; 20: 783-785https://doi.org/10.1007/s00383-004-1149-z
- Estimation of country-specific and global prevalence of male circumcision.Popul Health Metrics. 2016; 14https://doi.org/10.1186/s12963-016-0073-5
- Circumcision of male infants and children as a public health measure in developed countries: a critical assessment of recent evidence.Global Publ Health. 2018; 13: 626-641https://doi.org/10.1080/17441692.2016.1184292
- A review of 100 consecutive Sutureless child and adult circumcisions.Ir J Med Sci. 2011; 180: 51-53https://doi.org/10.1007/s11845-010-0545-8
- Sutureless circumcision - an Indian experience.Indian J Urol. 2011; 27: 475-478https://doi.org/10.4103/0970-1591.91435
- A novel, simple method for achieving hemostasis of fingertip dermal avulsion injuries.J Emerg Med. 2015; 48: 702-705https://doi.org/10.1016/j.jemermed.2014.12.083
- Endoscopic therapy with 2-Octyl-cyanoacrylate for the treatment of gastric varices.Dig Dis Sci. 2014; 59: 2178-2183https://doi.org/10.1007/s10620-014-3148-9
- The antibacterial effect of 2-octyl cyanoacrylate (Dermabond®) skin adhesive.J Infect Prev. 2014; 15: 236-239https://doi.org/10.1177/1757177414551562
- A prospective randomized controlled trial comparing N-butyl-2 cyanoacrylate (Histoacryl), octyl cyanoacrylate (Dermabond), and subcuticular suture for closure of surgical incisions.Ann Plast Surg. 2015; 74: 107-110https://doi.org/10.1097/SAP.0b013e318289856f
- Comparison of the late complications of circumcision in different age groups.J Compr Pediatr. 2017; 8https://doi.org/10.5812/compreped.59340
- Early and late complication of male circumcisions: a systematic review.Int J Med Dev Ctries. 2019; : 637-642https://doi.org/10.24911/IJMDC.51-1547424788
- Male circumcision complications–A systematic review, meta-analysis and meta-regression.Urology. 2021; 152: 25-34
Article info
Publication history
Published online: March 22, 2022
Accepted:
March 10,
2022
Received in revised form:
March 8,
2022
Received:
December 11,
2021
Identification
Copyright
© 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
