Music as an adjunct to combination analgesia for neonatal circumcision: A randomized controlled trial

Published:December 23, 2021DOI:https://doi.org/10.1016/j.jpurol.2021.12.011

      Summary

      Introduction

      Neonatal circumcision is one of the most frequently performed procedures in male infants; it is also particularly painful. In a previous trial, we showed that the combination of Eutectic Mixture of Local Anesthetics (EMLA) + Sucrose + Ring Block (RB) was significantly effective in reducing pain during circumcision.

      Objective

      In this study, we added music as an adjunct aiming to further reduce the pain scores.

      Study design

      This was a double-blinded randomized controlled trial comparing EMLA + Sucrose + RB (Control) to EMLA + Sucrose + RB + Music (Intervention). The trial setting was the normal nursery of a university teaching hospital. One hundred and three healthy newborn males were randomized to each of the intervention and control groups. Babies were videotaped (face and torso) during the procedure for assessment of pain by two blinded and independent reviewers. The primary outcome measure was the NIPS score; secondary outcomes included heart rate, oxygen saturation and crying time.

      Results

      The NIPS score of the intervention group (EMLA + Sucrose + RB + Music [2.6 ± 1.6]) was significantly higher than that of the control group (EMLA + sucrose + RB [1.4 ± 0.9]) (p = 0.00). Inter-rater reliability was high (κ .89). The intervention group registered significantly higher mean heart rate (142 bpm) and increased mean crying time (5.44 s) compared to the control group (135 bpm and 1.63s, respectively) (p = 0.01) and (p = 0.00). No adverse events were noted. Delivery music medicine by playing it from an iPad in the procedure room did not reduce pain during circumcision.

      Discussion

      There is overwhelming evidence in the literature describing the effectiveness of music on pain management especially in the NICU. However, our results did not align with the general trend; not only did music medicine fail to enhance analgesia but it might have had the opposite effect, further agitating the infants, as indicated by the significantly increased heart rate, crying time and NIPS scores of the participants in the intervention group. Limitations of our study include the fact that this is a single center study and the method of delivering music via iPads instead of noise-canceling headphone.

      Conclusion

      Our results showed that music, delivered in this manner, may have increased agitation. We affirm the fact that the combination of EMLA + Sucrose + RB is highly effective for managing pain during circumcision and further reduction of already low scores might not be possible.

      Clinical trial registration

      Summary Table
      Comparing NIPS scores between the Control and Intervention Groups
      EMLA + Sucrose + Ring Block (Control Grp.) EMLA + Sucrose + Ring Block + Music (Intervention Grp.) P
      Mean (SD) Mean (SD)
      Overall Scores 1.4 (0.97) 2.6 (1.64) <.001∗

      Keywords

      Abbreviations:

      AUBMC (American University of Beirut Medical Center), EMLA (Eutectic Mixture of Local Anesthetics), RB (Ring Block), WHO (World Health Organization), AAP (American Association of Pediatrics), NICU (Neonatal Intensive Care Unit), RCT (Randomized Controlled Trial), AABR (Automated Auditory Brainstem Response), OAE (Otoacoustic Emissions Testing), NIPS (Neonatal Infant Pain Scale)
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