Editorial comment: In this article by Riddle and colleagues, the authors evaluated outcomes of patients
with isolated bilateral renal agenesis (BRA) with or without fetal amino-infusion
therapy. In this retrospective case series, the authors identified 20 patients from
a single institution from 2004 to 2017. Even though the authors identified a total
of 47 patients with BRA, they focused only on patients from 2014 to 2017, a time period
when fetal intervention was offered for these patients at their institution. Between
2014 and 2017 the authors identified 20 singleton pregnancies with isolated fetal
BRA, of which 14 received at least a single amnioinfusion. Overall, 8 patients were
candidates for serial infusions (with therapeutic intent). Common complications of
amino-infusion therapy included chorioamniotic separation (63%), premature rupture
of membranes (25%), and chorioamnionitis (37.5%). No fetuses in the study survived
to discharge. Three in the serial infusion group survived past 48 h, with 2 surviving
past 30 days. However, both babies eventually succumb (day 33 and day 187) to sepsis
as a complication of dialysis.
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Article info
Publication history
Accepted:
November 22,
2021
Received:
November 22,
2021
Identification
Copyright
© 2021 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
