What the Editors are reading: Fetal urology

      Editorial comment: In this article by Riddle and colleagues, the authors evaluated outcomes of patients with isolated bilateral renal agenesis (BRA) with or without fetal amino-infusion therapy. In this retrospective case series, the authors identified 20 patients from a single institution from 2004 to 2017. Even though the authors identified a total of 47 patients with BRA, they focused only on patients from 2014 to 2017, a time period when fetal intervention was offered for these patients at their institution. Between 2014 and 2017 the authors identified 20 singleton pregnancies with isolated fetal BRA, of which 14 received at least a single amnioinfusion. Overall, 8 patients were candidates for serial infusions (with therapeutic intent). Common complications of amino-infusion therapy included chorioamniotic separation (63%), premature rupture of membranes (25%), and chorioamnionitis (37.5%). No fetuses in the study survived to discharge. Three in the serial infusion group survived past 48 h, with 2 surviving past 30 days. However, both babies eventually succumb (day 33 and day 187) to sepsis as a complication of dialysis.
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