Commentary to “Urinary Biomarkers Can Identify the Need for Pyeloplasty in Presence of Supranormal Differential Renal Function in Antenatally Diagnosed Unilateral Hydronephrosis”

Published:November 26, 2021DOI:https://doi.org/10.1016/j.jpurol.2021.10.027
      While the majority of prenatal hydronephrosis resolves, clinicians need to be able to reliably and accurately predict the small but important group in which it persists and impacts renal outcomes. Urinary biomarkers represent intriguing and attractive means of augmenting if not replacing current forms of diagnosing obstruction which almost exclusively rely on imaging. There is increasing evidence that specific urinary biomarkers, including those evaluated in the current study by Yucel et al., are differently expressed in those undergoing surgical correction of prenatal hydronephrosis as compared not only to healthy controls but also to those with prenatal hydronephrosis for whom surgery has not been deemed necessary [
      • Paraboschi I.
      • Mantica G.
      • Dalton N.R.
      • Turner C.
      • Garriboli M.
      Urinary biomarkers in pelvic-ureteric junction obstruction: a systematic review.
      ].
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      Reference

        • Paraboschi I.
        • Mantica G.
        • Dalton N.R.
        • Turner C.
        • Garriboli M.
        Urinary biomarkers in pelvic-ureteric junction obstruction: a systematic review.
        Transl Androl Urol. 2020; 9: 722-742

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