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Outcomes of event-free survival in patients with Wilms tumor undergoing preoperative chemotherapy. Analysis of lymph-node yield in a single-center cohort

Published:January 24, 2021DOI:https://doi.org/10.1016/j.jpurol.2020.12.029
      We read “Outcomes of event-free survival in patients with Wilms tumor undergoing preoperative chemotherapy. Analysis of lymph-node yield in a single-center cohort” by Flores et al. [
      • Flores P.
      • Cadario M.
      • Strambach J.
      • Sanjuanelo M.
      • Saleme J.M.
      • Paz E.
      • et al.
      Outcomes of event-free survival in patients with Wilms tumor undergoing preoperative chemotherapy. Analysis of lymph-node yield in a single-center cohort.
      ] The article piqued our interest, as studies observing the lymph node yield and its correlation with event free survival (EFS) in Wilms tumor patients from a center that follows (SIOP) protocols has been reported infrequently. Perhaps this is the only published study to observe outcomes with respect to lymph node involvement, after Jereb et al. [
      • Jereb B.
      • Tournade M.F.
      • Lemerle J.
      • Voǔte P.A.
      • Delemarre J.F.
      • Ahstrom L.
      • et al.
      Lymph node invasion and prognosis in nephroblastoma.
      ] Most of the studies reported were from the centres that followed NWTS/COG protocols, which described Lymph Node Yield (LNY) in a setting of up front surgery [
      • Kieran K.
      • Anderson J.R.
      • Dome J.S.
      • Ehrlich P.F.
      • Ritchey M.L.
      • Shamberger R.C.
      • et al.
      Lymph node involvement in wilms tumor: results from national wilms tumor studies 4 and 5.
      ,
      • Saltzman A.F.
      • Smith D.E.
      • Gao D.
      • Ghosh D.
      • Amini A.
      • Aldrink J.H.
      • et al.
      How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor.
      ,
      • Raval M.V.
      • Bilimoria K.Y.
      • Bentrem D.J.
      • Stewart A.K.
      • Winchester D.P.
      • Ko C.Y.
      • et al.
      Nodal evaluation in wilms' tumors: analysis of the national cancer data base.
      ,
      • Saltzman A.F.
      • Carrasco A.
      • Amini A.
      • Aldrink J.H.
      • Dasgupta R.
      • Gow K.W.
      • et al.
      Patterns of lymph node sampling and the impact of lymph node density in favorable histology Wilms tumor: an analysis of the national cancer database.
      ].
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      References

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        Outcomes of event-free survival in patients with Wilms tumor undergoing preoperative chemotherapy. Analysis of lymph-node yield in a single-center cohort.
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