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Preclinical studies of testicular ischemia-reperfusion treatment

Published:December 08, 2020DOI:https://doi.org/10.1016/j.jpurol.2020.10.034
      Testicular torsion occurs annually in appr. 3.8/100.000 under the age of 18 years The condition has a bimodal incidence pattern with peaks in infancy and early adolescence [
      • Zhao L.C.
      • Lautz T.B.
      • Meeks J.J.
      • Maizels M.
      Pediatric testicular torsion epidemiology using a national database: incidence, risk of orchiectomy and possible measures toward improving of care.
      ]. If retorsion is performed within the first few hours, there might be a chance of preservation of testicular function, but when the time period from onset of symptoms exceeds 12 h, the testicular function is lost. So acute surgery is mandatory, but could it be possible to get a higher success rate with supplementary measures? This is the topic of the preclinical study by [
      • Tanriverdi H.I.
      • Senel U.
      • Gevrek F.
      • Akbas A.
      Protective effect of famotidine on ischemia-reperfusion injury following testicular torsion in rats.
      ] where they explore the effect of famotidine, a competitive inhibitor of histamine H2 receptors, normally used to reduce gastric acid, to counteract the reperfusion damages to the testicular tissue?
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      References

        • Zhao L.C.
        • Lautz T.B.
        • Meeks J.J.
        • Maizels M.
        Pediatric testicular torsion epidemiology using a national database: incidence, risk of orchiectomy and possible measures toward improving of care.
        J Urol. 2011; 186: 2009-2013
        • Tanriverdi H.I.
        • Senel U.
        • Gevrek F.
        • Akbas A.
        Protective effect of famotidine on ischemia-reperfusion injury following testicular torsion in rats.
        J Pediatr Urol. 2021; 17: 167
        • Arena S.
        • Iacona R.
        • Antonuccio P.
        • Russo T.
        • Salvo V.
        • Gitto E.
        • et al.
        Medical perspective in testicular ischemia-reperfusion injury (Review).
        Exp and Therapeut Med. 2017; 13: 2115-2122

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