Testicular torsion occurs annually in appr. 3.8/100.000 under the age of 18 years
The condition has a bimodal incidence pattern with peaks in infancy and early adolescence
[
[1]
]. If retorsion is performed within the first few hours, there might be a chance of
preservation of testicular function, but when the time period from onset of symptoms
exceeds 12 h, the testicular function is lost. So acute surgery is mandatory, but
could it be possible to get a higher success rate with supplementary measures? This
is the topic of the preclinical study by [
[2]
] where they explore the effect of famotidine, a competitive inhibitor of histamine
H2 receptors, normally used to reduce gastric acid, to counteract the reperfusion
damages to the testicular tissue?To read this article in full you will need to make a payment
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References
- Pediatric testicular torsion epidemiology using a national database: incidence, risk of orchiectomy and possible measures toward improving of care.J Urol. 2011; 186: 2009-2013
- Protective effect of famotidine on ischemia-reperfusion injury following testicular torsion in rats.J Pediatr Urol. 2021; 17: 167
- Medical perspective in testicular ischemia-reperfusion injury (Review).Exp and Therapeut Med. 2017; 13: 2115-2122
Article info
Publication history
Published online: December 08, 2020
Accepted:
October 24,
2020
Received in revised form:
October 23,
2020
Received:
October 1,
2020
Identification
Copyright
© 2020 Published by Elsevier Ltd on behalf of Journal of Pediatric Urology Company.
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- Protective effect of famotidine on ischemia–reperfusion injury following testicular torsion in ratsJournal of Pediatric UrologyVol. 17Issue 2
