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Letter to the editor regarding “Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?” by Ünsal Özkuvancı, M. İrfan Dönmez, Orhan Ziylan, Tayfun Oktar, Canan Küçükgergin, Bilal Çetin, Selçuk Erdem, Şule Seçkin

  • Antigoni Pavlaki
    Correspondence
    Correspondence to: Antigoni Pavlaki, Paediatric Nephrology Unit, First Department of Paediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49th Konstantinoupoleos Street, 546 42 Thessaloniki, Greece, Tel.: +30 2310892466.
    Affiliations
    Paediatric Nephrology Unit, First Department of Paediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece
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  • Christos Kaselas
    Affiliations
    Second Department of Pediatric Surgery, Aristotle University of Thessaloniki, “Papageorgiouˮ General Hospital, Thessaloniki, Greece
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  • Evangelia Farmaki
    Affiliations
    Paediatric Nephrology Unit, First Department of Paediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece
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  • Fotios Papachristou
    Affiliations
    Paediatric Nephrology Unit, First Department of Paediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece
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  • Nikoleta Printza
    Affiliations
    Paediatric Nephrology Unit, First Department of Paediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece
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Published:November 15, 2020DOI:https://doi.org/10.1016/j.jpurol.2020.10.032
      We read the excellent, manuscript of Özkuvancı et al. [
      • Özkuvancı Ü.
      • İrfan Dönmez M.
      • Ziylan O.
      • Oktar T.
      • Küçükgergin C.
      • Çetin B.
      • et al.
      Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?.
      ] with great interest since we have also studied infants and children with antenatal hydronephrosis (AH) who were treated for obstruction and with non-obstructive hydronephrosis who were monitored systematically [
      • Pavlaki A.
      • Printza N.
      • Farmaki E.
      • Stabouli S.
      • Taparkou A.
      • Sterpi M.
      • et al.
      The role of urinary NGAL and serum cystatin C in assessing the severity of ureteropelvic junction obstruction in infants.
      ]. In this prospective study urinary biomarkers were evaluated in terms of differentiating obstruction from non-obstructive dilation in patients with AH that underwent pyeloplasty due to loss of differential renal function (DRF) [
      • Özkuvancı Ü.
      • İrfan Dönmez M.
      • Ziylan O.
      • Oktar T.
      • Küçükgergin C.
      • Çetin B.
      • et al.
      Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?.
      ]. They measured urinary IP-10, MCP-1, KIM-1, NGAL, and Ca19-9 levels using ELISA. According to their results KIM-1 was the most successful among all the biomarkers evaluated.
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