We read the excellent, manuscript of Özkuvancı et al. [
[1]
] with great interest since we have also studied infants and children with antenatal
hydronephrosis (AH) who were treated for obstruction and with non-obstructive hydronephrosis
who were monitored systematically [
- Özkuvancı Ü.
- İrfan Dönmez M.
- Ziylan O.
- Oktar T.
- Küçükgergin C.
- Çetin B.
- et al.
Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal
hydronephrosis?.
J Pediatr Urol. 2020; S1477–5131 (Epub ahead of print. PMID: 32988771): 30530-30531https://doi.org/10.1016/j.jpurol.2020.09.005
[2]
]. In this prospective study urinary biomarkers were evaluated in terms of differentiating
obstruction from non-obstructive dilation in patients with AH that underwent pyeloplasty
due to loss of differential renal function (DRF) [
[1]
]. They measured urinary IP-10, MCP-1, KIM-1, NGAL, and Ca19-9 levels using ELISA.
According to their results KIM-1 was the most successful among all the biomarkers
evaluated.- Özkuvancı Ü.
- İrfan Dönmez M.
- Ziylan O.
- Oktar T.
- Küçükgergin C.
- Çetin B.
- et al.
Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal
hydronephrosis?.
J Pediatr Urol. 2020; S1477–5131 (Epub ahead of print. PMID: 32988771): 30530-30531https://doi.org/10.1016/j.jpurol.2020.09.005
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References
- Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?.J Pediatr Urol. 2020; S1477–5131 (Epub ahead of print. PMID: 32988771): 30530-30531https://doi.org/10.1016/j.jpurol.2020.09.005
- The role of urinary NGAL and serum cystatin C in assessing the severity of ureteropelvic junction obstruction in infants.Pediatr Nephrol. 2020; 35: 163-170
- Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosis.J Pediatr Urol. 2015; 11 (249.e1–249.e6)
- Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: a pilot study.J Pediatr Urol. 2016; 12 (120.e1-120.e7)
- Potential novel biomarkers of obstructive nephropathy in children with hydronephrosis.Dis Markers. 2018; 2018: 1015726
Article info
Publication history
Published online: November 15, 2020
Accepted:
October 26,
2020
Received:
October 22,
2020
Identification
Copyright
© 2020 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
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- Response to letter to the editor re ‘Can urinary biomarkers detect obstruction defined by renal functional loss in antenatal hydronephrosis?’Journal of Pediatric UrologyVol. 17Issue 1
- PreviewWe appreciate our colleagues' interest in our article [1]. There have been some well-defined problems in urinary biomarker studies throughout the 15 years of ongoing research that precluded urinary biomarkers to become a tool in daily practice for children with antenatal hydronephrosis. These difficulties include lack of standardization in studies, timing/type of urine sampling, absence of standardized clinical group definitions, and last but not the least little knowledge on normal biomarker levels by age.
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