Journal of Pediatric Urology
Volume 5, Issue 6 , Pages 430-436 , December 2009

Botulinum toxin type A for neurogenic detrusor overactivity due to spinal cord lesions in children: A retrospective study of seven cases

  • C. Do Ngoc Thanh

      Affiliations

    • Unité pédiatrique de Médecine Physique et Réadaptation – Groupe Hospitalier Universitaire Trousseau – La Roche Guyon, Université Pierre et Marie Curie, Paris, France
    • ,
  • G. Audry

      Affiliations

    • Service de chirurgie viscérale pédiatrique Groupe Hospitalier Universitaire Trousseau – La Roche Guyon, Université Pierre et Marie Curie, Paris, France
    • ,
  • V. Forin

      Affiliations

    • Unité pédiatrique de Médecine Physique et Réadaptation – Groupe Hospitalier Universitaire Trousseau – La Roche Guyon, Université Pierre et Marie Curie, Paris, France
    • Corresponding Author InformationCorresponding author. Unité pédiatrique de médecine physique et de réadaptation, Groupe Hospitalier Universitaire Trousseau – La Roche Guyon, 26 avenue du Docteur Arnold Netter 75012 Paris, France. Tel.: +33 1 44 73 62 26; fax: +33 1 44 73 63 24.

Received 18 December 2008 ,Accepted 1 June 2009.

References 

  1. Neveus T, von Gontard A, Hoebeke P, Hjalmas K, Bauer S, Bower W, et al. The standardization of terminology of lower urinary tract function in children and adolescents: report from the standardisation committee of the international children's continence society. J Urol. 2006;176:314–324
  2. Rigaud J, Le Normand L. Augmentation enterocystoplasty. Ann Urol (Paris). 2004;38:298–310
  3. Schurch B, Stohrer M, Kramer G, Schmid DM, Gaul G, Hauri D. Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results. J Urol. 2000;164:692–697
  4. Schulte-Baukloh H, Michael T, Schobert J, Stolze T, Knispel HH. Efficacy of botulinum-a toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary results. Urology. 2002;59:327–328(discussion 325, 7)
  5. Schulte-Baukloh H, Michael T, Sturzebecher B, Knispel HH. Botulinum-a toxin detrusor injection as a novel approach in the treatment of bladder spasticity in children with neurogenic bladder. Eur Urol. 2003;44:139–143
  6. Schulte-Baukloh H, Knispel HH, Stolze T, Weiss C, Michael T, Miller K. Repeated botulinum-A toxin injections in treatment of children with neurogenic detrusor overactivity. Urology. 2005;66:865–870(discussion 870)
  7. Riccabona M, Koen M, Schindler M, Goedele B, Pycha A, Lusuardi L, et al. Botulinum-A toxin injection into the detrusor: a safe alternative in the treatment of children with myelomeningocele with detrusor hyperreflexia. J Urol. 2004;171:845–848(discussion 848)
  8. Kajbafzadeh AM, Moosavi S, Tajik P, Arshadi H, Payabvash S, Salmasi AH, et al. Intravesical injection of botulinum toxin type A: management of neuropathic bladder and bowel dysfunction in children with myelomeningocele. Urology. 2006;68:1096–1097(1091, 6; discussion)
  9. Azemar MD, Fiquet C, Lefebvre F, Bouche Pillon MA, Lefort G, Poli-Merol ML. Toxine botulique intra détrusorienne dans le traitement de l'hyperactivité vésicale de l'enfant. Etude préliminaire à propos de 6 cas. Arch Pediatr. 2006;13:863
  10. Altaweel W, Jednack R, Bilodeau C, Corcos J. Repeated intradetrusor botulinum toxin type A in children with neurogenic bladder due to myelomeningocele. J Urol. 2006;175:1102–1105
  11. Dobremez E, Llanas B, Shao E, de Seze M. Indications and results of intradetrusor of botulinum toxin type A injections in children. Prog Urol. 2008;18:168–171
  12. Akbar M, Abel R, Seyler TM, Bedke J, Haferkamp A, Gerner HJ, et al. Repeated botulinum-A toxin injections in the treatment of myelodysplastic children and patients with spinal cord injuries with neurogenic bladder dysfunction. BJU Int. 2007;100:639–645
  13. Palmer LS, Richards I, Kaplan WE. Age related bladder capacity and bladder capacity growth in children with myelomeningocele. J Urol. 1997;158:1261–1264
  14. Karsenty G, Denys P, Amarenco G, De Seze M, Game X, Haab F, et al. Botulinum toxin A (botox) intradetrusor injections in adults with neurogenic detrusor overactivity/neurogenic overactive bladder: a systematic literature review. Eur Urol. 2008;53:275–287
  15. Kuehn BM. Studies, reports say botulinum toxins may have effects beyond injection site. J Am Med Assoc. 2008;299:2261–2263
  16. Grosse J, Kramer G, Stohrer M. Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence. Eur Urol. 2005;47:653–659
  17. Karsenty G, Reitz A, Lindemann G, Boy S, Schurch B. Persistence of therapeutic effect after repeated injections of botulinum toxin type A to treat incontinence due to neurogenic detrusor overactivity. Urology. 2006;68:1193–1197
  18. Chenet A, Perrouin-Verbe B, Le Normand L, Labat JJ, Brunel P, Lefort M, et al. Efficacy of repeat injections of botulinum A toxin to the detrusor in neurogenic bladder overactivity. Ann Readapt Med Phys. 2007;50:651–660
  19. Haferkamp A, Schurch B, Reitz A, Krengel U, Grosse J, Kramer G, et al. Lack of ultrastructural detrusor changes following endoscopic injection of botulinum toxin type a in overactive neurogenic bladder. Eur Urol. 2004;46:784–791

PII: S1477-5131(09)00358-1

doi: 10.1016/j.jpurol.2009.06.001

Journal of Pediatric Urology
Volume 5, Issue 6 , Pages 430-436 , December 2009

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