Journal of Pediatric Urology
Volume 5, Issue 3 , Pages 156-164 , June 2009

Botulinum toxin-A (Botox®) intradetrusor injections in children with neurogenic detrusor overactivity/neurogenic overactive bladder: A systematic literature review

  • Xavier Gamé

      Affiliations

    • Hôpital Rangueil, Toulouse, France
    • Corresponding Author InformationCorrespondence to: Dr Xavier Gamé, Service d'Urologie, Andrologie et Transplantation Rénale, CHU Rangueil, TSA 50032, 31059 Toulouse Cedex, France. Tel.: +335 61 323 229; fax: +335 61 323 230.
    • ,
  • Pascal Mouracade

      Affiliations

    • Hôpital Civil, Strasbourg, France
    • ,
  • Emmanuel Chartier-Kastler

      Affiliations

    • Hôpital Pitié-Salpêtrière, Paris, France
    • ,
  • Elke Viehweger

      Affiliations

    • Hôpital Timone-Enfants, Marseille, France
    • ,
  • Raphael Moog

      Affiliations

    • Hôpital Civil, Strasbourg, France
    • ,
  • Gérard Amarenco

      Affiliations

    • Hôpital Rothschild, Paris, France
    • ,
  • Pierre Denys

      Affiliations

    • Hôpital Raymond Poincaré, Garches, France
    • ,
  • Marianne De Seze

      Affiliations

    • Hôpital Pellegrin, Bordeaux, France
    • ,
  • François Haab

      Affiliations

    • Hôpital Tenon, Paris, France
    • ,
  • Gilles Karsenty

      Affiliations

    • Hôpital Sainte Marguerite, Marseille, France
    • ,
  • Jacques Kerdraon

      Affiliations

    • Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Ploemeur, France
    • ,
  • Brigitte Perrouin-Verbe

      Affiliations

    • Hôpital St Jacques, Nantes, France
    • ,
  • Alain Ruffion

      Affiliations

    • Hôpital Henry Gabrielle, Saint Genis Laval, France
    • ,
  • Jean-Marc Soler

      Affiliations

    • Centre Bouffard Vercelli, Cerbère, France
    • ,
  • Christian Saussine

      Affiliations

    • Hôpital Civil, Strasbourg, France

Received 25 November 2008 ,Accepted 10 January 2009.

References 

  1. Gamé X, Grima F, Chartier-Kastler E, Ruffion A. Troubles vésico-sphinctériens et sexuels des spina bidida et myélomeningocèles. Prog Urol. 2007;17:352–357
  2. Hernandez RD, Hurwitz RS, Foote JE, Zimmern PE, Leach GE. Nonsurgical management of threatened upper urinary tracts and incontinence in children with myelomeningocele. J Urol. 1994;152:1582–1585
  3. Van Ermengem E. Ueber einen neuen anaeroben Bacillus und seine Beziehungen zum Botulismus. Zeitsch Hyg Infekt. 1897;26:1–56
  4. Montecucco C, Schiavo G. Structure and function of tetanus and botulinum neurotoxins. Q Rev Biophys. 1995;28:423–472
  5. Chapple C, Patel A. Botulinum toxin – new mechanisms, new therapeutic directions?. Eur Urol. 2006;49:606–608
  6. Apostolidis A, Dasgupta P, Fowler CJ. Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivity. Eur Urol. 2006;49:644–650
  7. Heinen F, Molenaers G, Fairhurst C, Carr LJ, Desloovere K, Chaleat Valayer E, et al. European consensus table 2006 on botulinum toxin for children with cerebral palsy. Eur J Paediatr Neurol. 2006;10:215–225
  8. Dykstra DD, Sidi AA. Treatment of detrusor–sphincter dyssynergia with botulinum A toxin: a double-blind study. Arch Phys Med Rehabil. 1990;71:24–26
  9. Stöhrer M, Schurch B, Kramer G, Schmidt D, Gaul D, Hauri D. Botulinum A toxin in the treatment of detrusor hyperreflexia in spinal cord injury. A new alternative to medical and surgical procedures?. Neurourol Urodyn. 1999;18:401–402
  10. Schulte-Baukloh H, Michael T, Schobert J, Stolze T, Knispel HH. Efficacy of botulinum-A toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary results. Urology. 2002;59:325–327[discussion: 327–8]
  11. Schulte-Baukloh H, Michael T, Sturzebecher B, Knispel HH. Botulinum-A toxin detrusor injection as a novel approach in the treatment of bladder spasticity in children with neurogenic bladder. Eur Urol. 2003;44:139–143
  12. Riccabona M, Koen M, Schindler M, Goedele B, Pycha A, Lusuardi L, et al. Botulinum-A toxin injection into the detrusor: a safe alternative in the treatment of children with myelomeningocele with detrusor hyperreflexia. J Urol. 2004;171:845–848
  13. Schulte-Baukloh H, Knispel HH, Stolze T, Weiss C, Michael T, Miller K. Repeated botulinum-A toxin injections in treatment of children with neurogenic detrusor overactivity. Urology. 2005;66:865–870
  14. Altaweel W, Jednack R, Bilodeau C, Corcos J. Repeated intradetrusor botulinum toxin type A in children with neurogenic bladder due to myelomeningocele. J Urol. 2006;175:1102–1105
  15. Kajbafzadeh AM, Moosavi S, Tajik P, Arshadi H, Payabvash S, Salmasi AH, et al. Intravesical injection of botulinum toxin type A: management of neuropathic bladder and bowel dysfunction in children with myelomeningocele. Urology. 2006;68:1091–1096[discussion: 1096–7]
  16. McGuire EJ, Savastano JA. Urodynamics and management of the neuropathic bladder in spinal cord injury patients. J Am Paraplegia Soc. 1985;8:28–32
  17. Karsenty G, Denys P, Amarenco G, De Seze M, Game X, Haab F, et al. Botulinum toxin a (Botox®) intradetrusor injections in adults with neurogenic detrusor overactivity/neurogenic overactive bladder: a systematic literature review. Eur Urol. 2008;53:275–287
  18. Schurch B, Schmid DM, Stohrer M. Treatment of neurogenic incontinence with botulinum toxin A. N Engl J Med. 2000;342:665
  19. Neel KF, Soliman S, Salem M, Seida M, Al-Hazmi H, Khatab A. Botulinum-A toxin: solo treatment for neuropathic noncompliant bladder. J Urol. 2007;178:2593–2597[discussion: 2597–8]
  20. Molenaers G, Desloovere K, Eyssen M, De Cat J, Jonkers I, De Cock P. Botulinum toxin type A treatment of cerebral palsy: an integrated approach. Eur J Neurol. 1999;6:S51–S57
  21. Molenaers G, Desloovere K, Fabry G, De Cock P. The effects of quantitative gait assessment and botulinum toxin A on musculoskeletal surgery in children with cerebral palsy. J Bone Joint Surg Am. 2006;88:161–170
  22. Heinen F, Schroeder AS, Fietzek U, Berweck S. When it comes to botulinum toxin, children and adults are not the same: multimuscle option for children with cerebral palsy. Mov Disord. 2006;21:2029–2030
  23. Bartonek A, Gutierrez EM, Haglund-Akerlind Y, Saraste H. The influence of spasticity in the lower limb muscles on gait pattern in children with sacral to mid-lumbar myelomeningocele: a gait analysis study. Gait Posture. 2005;22:10–25
  24. Ozaras N, Yalcin S, Ofluoglu D, Gureri B, Cabukoglu C, Erol B. Are some cases of spina bifida combined with cerebral palsy? A study of 28 cases. Eura Medicophys. 2005;41:239–242
  25. Heinen F, Korinthenberg R, Stücker R, Deuschl G. Dystonic posture of lower extremities associated with myelomeningocele: successful treatment with botulinum A toxin in a sixmonth-old child. Neuropediatrics. 1995;26:214–216

PII: S1477-5131(09)00013-8

doi: 10.1016/j.jpurol.2009.01.005

Journal of Pediatric Urology
Volume 5, Issue 3 , Pages 156-164 , June 2009

Article Tools

* Image Usage & Resolution