Journal of Pediatric Urology
Volume 5, Issue 4 , Pages 283-286 , August 2009

Maternal and fetal risk factors associated with severity of hypospadias: A comparison of mild and severe cases

  • William H. Carlson

      Affiliations

    • Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada
  • ,
  • Stephen R. Kisely

      Affiliations

    • Queensland Centre for Health Data Services, University of Queensland, Queensland, Australia
    • Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
  • ,
  • Dawn L. MacLellan

      Affiliations

    • Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada
    • Corresponding Author InformationCorresponding author. Department of Urology, Dalhousie University, P.O. Box 9700, 5850/5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8. Tel.: +902 470 8943; fax: +902 470 8267.

Received 21 October 2008 ,Accepted 10 December 2008.

References 

  1. Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadias trends in two US surveillance systems. Pediatrics. 1997;100:831
  2. Paulozzi LJ. International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect. 1999;107:297
  3. Carmichael SL, Shaw GM, Nelson V, Selvin S, Torfs CP, Curry CJ. Hypospadias in California: trends and descriptive epidemiology. Epidemiology. 2003;14:701
  4. Porter MP, Faizan MK, Grady RW, Mueller BA. Hypospadias in Washington State: maternal risk factors and prevalence trends. Pediatrics. 2005;115:e495
  5. Schnack TH, Zdravkovic S, Myrup C, Westergaard T, Christensen K, Wohlfahrt J, et al. Familial aggregation of hypospadias: a cohort study. Am J Epidemiol. 2008;167:251
  6. Wang MH, Baskin LS. Endocrine disruptors, genital development and hypospadias. J Androl. 2008;29(5):499–505
  7. Waller DK, Shaw GM, Rasmussen SA, Hobbs CA, Canfield MA, Siega-Riz AM, et al. Prepregnancy obesity as a risk factor for structural birth defects. Arch Pediatr Adolesc Med. 2007;161:745
  8. Carmichael SL, Shaw GM, Laurent C, Olney RS, Lammer EJ, National Birth Defects Prevention Study . Maternal reproductive and demographic characteristics as risk factors for hypospadias. Paediatr Perinat Epidemiol. 2007;21:210
  9. Brouwers MM, Feitz WF, Roelofs LA, Kiemeney LA, de Gier RP, Roeleveld N. Risk factors for hypospadias. Eur J Pediatr. 2007;166:671
  10. Chong JH, Wee CK, Ho SK, Chan DK. Factors associated with hypospadias in Asian newborn babies. J Perinat Med. 2006;34:497
  11. Fujimoto T, Suwa T, Kabe K, Adachi T, Nakabayashi M, Amamiya T. Placental insufficiency in early gestation is associated with hypospadias. J Pediatr Surg. 2008;43:358
  12. Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi AM, et al. Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. J Clin Endocrinol Metab. 2005;90:4041
  13. Fisch H, Golden RJ, Libersen GL, Hyun GS, Madsen P, Hensle TW, et al. Maternal age as a risk factor for hypospadias. J Urol. 2001;165:934
  14. Nova Scotia Community Counts. Halifax, Province of Nova Scotia; 2007. Available: <www.gov.ns.ca/finance/communitycounts/topicresults.asp?s=demographics> [accessed 20 November 2008].
  15. Reefhuis J, Honein MA. Maternal age and non-chromosomal birth defects, Atlanta – 1968–2000: teenager or thirty-something, who is at risk?. Birth Defects Res A Clin Mol Teratol. 2004;70:572
  16. Fernandez MF, Olmos B, Granada A, Lopez-Espinosa MJ, Molina-Molina JM, Fernandez JM, et al. Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study. Environ Health Perspect. 2007;115:8
  17. Pulkrabova J, Hradkova P, Hajslova J, Poustka J, Napravnikova M, Polacek V. Brominated flame retardants and other organochlorine pollutants in human adipose tissue samples from the Czech Republic. Environ Int. 2009;35(1):63–68
  18. Hodges LC, Bergerson JS, Hunter DS, Walker CL. Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol Sci. 2000;54:355
  19. Tiemann U. In vivo and in vitro effects of the organochlorine pesticides DDT, TCPM, methoxychlor, and lindane on the female reproductive tract of mammals: a review. Reprod Toxicol. 2008;25:316
  20. Ali T, Bhalli JA, Rana SM, Khan QM. Cytogenetic damage in female Pakistani agricultural workers exposed to pesticides. Environ Mol Mutagen. 2008;49:374
  21. Kallen B, Finnstrom O, Nygren KG, Olausson PO. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res A Clin Mol Teratol. 2005;73:162
  22. Carmichael SL, Shaw GM, Laurent C, Lammer EJ, Olney RS, National Birth Defects Prevention Study . Hypospadias and maternal exposures to cigarette smoke. Paediatr Perinat Epidemiol. 2005;19:406

PII: S1477-5131(08)00452-X

doi: 10.1016/j.jpurol.2008.12.005

Journal of Pediatric Urology
Volume 5, Issue 4 , Pages 283-286 , August 2009