Journal of Pediatric Urology
Volume 5, Issue 1 , Pages 13-16, February 2009

The molecular pathways behind bladder stretch injury

The Department of Urology and the Pediatric Urology Service, Rambam Medical Center, and the Faculty of Medicine, Technion Israeli Institute of Technology, P.O. Box 9602, Haifa 31096, Israel

Received 8 May 2008; accepted 5 August 2008. published online 15 September 2008.

Abstract 

Stretch injury is a non-reversible process that changes the cellular and extracellular characteristics of the bladder wall, leading to bladder dysfunction. Posterior urethral valve and neurogenic bladder are examples of disorders that may lead to stretch injury. There is a lack of understanding of the molecular processes leading to stretch injury. The current literature is reviewed in this paper, with the aim of giving some insight into the molecular and genetic pathways of bladder stretch injury.

Keywords: Bladder stretch injury, Molecular pathway, Pathophysiology, Research models

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PII: S1477-5131(08)00357-4

doi:10.1016/j.jpurol.2008.08.003

Journal of Pediatric Urology
Volume 5, Issue 1 , Pages 13-16, February 2009

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