Journal of Pediatric Urology
Volume 4, Issue 3 , Pages 221-228 , June 2008

Endoscopic treatment of vesicoureteral reflux using dextranomer hyaluronic acid copolymer

  • Joseph A. Molitierno
    • ,
  • Hal C. Scherz
    • ,
  • Andrew J. Kirsch

      Affiliations

    • Corresponding Author InformationCorresponding author. Children's Healthcare of Atlanta, Emory University School of Medicine, 5445 Meridian Mark Road, Suite 420, Atlanta, GA 30342, USA. Tel.: +1 404 252 5206; fax: +1 404 252 1268.

Received 24 August 2007 ,Accepted 26 November 2007.

References 

  1. Smellie J, Edwards D, Hunter N, Normand IC, Prescod N. Vesico-ureteric reflux and renal scarring. Kidney Int Suppl. 1975 Aug;4:S65–S72
  2. Bailey R. Vesicoureteric reflux in healthy infants and children. In:  Hodson J,  Kincaid-Smith P editor. Reflux nephropathy. New York: Masson Publishing; 1979;p. 59–61
  3. Jacobson SH, Hansson S, Jakobsson B. Vesico-ureteric reflux: occurrence and long-term risks. Acta Paediatr. 1999;88:22–30
  4. Lendvay TS, Sorensen M, Cowan CA, Joyner BD, Mitchell MM, Grady RW. The evolution of vesicoureteral reflux management in the era of dextranomer/hyaluronic acid copolymer: a pediatric health information system database study. J Urol. 2006;176:1864–1867
  5. Stenberg A, Lackgren G. Treatment of vesicoureteral reflux in children using stabilized non-animal hyaluronic acid/dextranomer gel (NASHA/DX): a long-term observational study. J Pediatr Urol. 2007;3:80–85
  6. Ogan K, Pohl H, Carlson D, Belman B, Rushton G. Parental preferences in the management of vesicoureteral reflux. J Urol. 2001;166:240
  7. Capozza N, Lais A, Matarazzo E, Nappo S, Patricolo M, Caione P. Treatment of vesico-ureteric reflux: a new algorithm based on parental preference. BJU Int. 2003;92:285–288
  8. Hensle TW, Hyun G, Grogg A, Eaddy M. Examining pediatric vesicoureteral reflux: a real-world evaluation of treatment patterns and outcomes. American Urological Association Annual Meeting, 20–25 May 2006, Atlanta, Georgia [abstract 761].
  9. Molitierno JA, Watson JM, Scherz HC, Kirsch AJ. Paradigm shift in the surgical management of vesicoureteral reflux: 21st century treatment of a 20th century problem. American Urological Association Annual Meeting, 19–24 May 2007, Anaheim, California [abstract 60].
  10. Matouschek E. New concept for the treatment of vesico-ureteral reflux. Endoscopic application of Teflon. Arch Esp Urol. 1981;34:385
  11. Puri P, Ninan GK, Surana R. Subureteric Teflon injection (STING). Results from a European Survey. Eur Urol. 1995;27:71
  12. Lackgren G, Wahlin N, Skoldenberg E, Stenberg A. Long-term followup of children treated with dextranomer/hyaluronic acid copolymer for vesicoureteral reflux. J Urol. 2001;166:1887
  13. Lackgren G, Wahlin N, Skoldenberg E, Neveus T, Stenberg A. Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid copolymer is effective in either double ureters or a small kidney. J Urol. 2003;170:1551–1555
  14. Kirsch AJ, Perez-Brayfield M, Smith EA, Scherz HC. The modified STING procedure to correct vesicoureteral reflux: improved results with submucosal implantation within the intramural ureter. J Urol. 2004 Jun;171(6 Pt 1):2413–2416
  15. Yu RN, Roth DR. Treatment of vesicoureteral reflux using endoscopic injection of nonanimal stabilized hyaluronic acid/dextranomer gel: initial experience in pediatric patients by a single surgeon. Pediatrics. 2006;118:698–703
  16. Elder J, Diaz M, Caldamone AA. Endoscopic therapy for vesicoureteral reflux: a meta-analysis. I. Reflux resolution and urinary tract infection. J Urol. 2003;175:716–722
  17. Capozza N, Lais A, Matarazzo E, Nappo S, Patricolo M, Caione P. Influence of voiding dysfunction on the outcome of endoscopic treatment for vesicoureteral reflux. J Urol. 2002 Oct;168(4 Pt 2):1695–1698
  18. Capozza N, Lais A, Nappo S, Caione P. The role of endoscopic treatment of vesicoureteral reflux: a 17-year experience. J Urol. 2004;172:1626–1629
  19. Lackgren G, Skoldenberg E, Stenberg A. Endoscopic treatment with stabilized nonanimal hyaluronic acid/dextranomer gel is effective in vesicoureteral reflux associated with bladder dysfunction. J Urol. 2007;177:1124–1129
  20. Perez-Brayfield M, Kirsch AJ, Hensle TW, Koyle MA, Furness P, Scherz HC. Endoscopic treatment with dextranomer/hyaluronic acid for complex cases of vesicoureteral reflux. J Urol. 2004;172:1614–1616
  21. Elder JS, Peters CA, Arant BS, et al. Pediatric vesicoureteral reflux guidelines panel summary report on the management of primary vesicoureteral reflux in children. J Urol. 1997;157:1846–1851
  22. Cerwinka WH, Scherz HC, Kirsch AJ. Endoscopic treatment of vesicoureteral reflux associated with paraureteral diverticula in children. J Urol. 2007;178:1469–1473
  23. Kitchens D, Minevich E, DeFoor W, Reddy P, Wacksman J, Sheldon C, et al. Endoscopic injection of dextranomer/hyaluronic acid copolymer to correct vesicoureteral reflux following failed ureteroneocystostomy. J Urol. 2006;176:1861–1863
  24. Jung C, DeMarco RT, Lowrance WT, Pope JC, Adams MC, Dietrich MS, et al. Subureteral injection of dextranomer/hyaluronic acid copolymer for persistent vesicoureteral reflux following ureteroneocystostomy. J Urol. 2007;177:312–315
  25. Kumar R, Puri P. Newly diagnosed contralateral reflux after successful unilateral endoscopic correction: is it due to the pop-off mechanism?. J Urol. 1997;158:1213–1215
  26. Williams DI. Vesico-ureteric reflux. In:  Williams DI,  Barratt TM,  Eckstein HB,  Kohlinsky SM,  Newns GH,  Polani PE, et al. editor. Urology in childhood. New York: Springer-Verlag; 1974;p. 111–136
  27. Diamond DA, Rabinowitz R, Hoenig DM, Caldamone AA. The mechanism of new onset contralateral reflux following unilateral ureteroneocystostomy. J Urol. 1996;156:665
  28. Noe HN. The risk and risk factors of contralateral reflux following repair of simple unilateral primary reflux. J Urol. 1998;160:849–850
  29. Elmore JM, Kirsch AJ, Lyles RH, Perez-Brayfield MR, Scherz HC. New contralateral vesicoureteral reflux following dextranomer/hyaluronic acid implantation: incidence and identification of a high risk group. J Urol. 2006;175:1097–1101
  30. Kirsch AJ, Elmore JM, Lyles RH, Scherz HC. Dynamic hydrodistention classification of the ureteral orifice is predictive of the severity of vesicoureteral reflux and correlates with the presence of febrile urinary tract infections. American Urological Association Annual Meeting, 20–25 May 2006, Atlanta, Georgia [abstract 758].
  31. Wheeler DM, Vimalachandra D, Hodson EM, Smith GH, Craig JC. Interventions for primary vesicoureteral reflux. Cochrane Database Syst Rev. 2004;3:CD001532
  32. Lavelle M, Skoog S. Subureteral injection of deflux for correction of reflux: analysis of factors predicting success. Urology. 2005;65:564–567
  33. Yucel S, Gupta A, Snodgrass W. Multivariate analysis of factors predicting success with dextranomer/hyaluronic acid injection for vesicoureteral reflux. J Urol. 2007;177:1505–1509
  34. Higham-Kessler J, Reinert SE, Snodgrass WT, et al. A review of failures of endoscopic treatment of vesicoureteral reflux with dextranomer microspheres. J Urol. 2007;177:710–715
  35. Elmore JM, Scherz HC, Kirsch AJ. Dextranomer/hyaluronic acid for vesicoureteral reflux: success rates after initial treatment failure. J Urol. 2006;175:712–715
  36. Elmore JM, Kirsch AJ, Perez-Brayfield MR, Scherz HC, Koyle MA. Salvage extravesical ureteral reimplantation after failed endoscopic surgery for vesicoureteral reflux. J Urol. 2006;176:1158–1160
  37. McMann LP, Scherz HC, Kirsch AJ. Long-term preservation of dextranomer/hyaluronic acid copolymer implants after endoscopic treatment of vesicoureteral reflux in children: a sonographic volumetric analysis. J Urol. 2007;177:316–320
  38. Molitierno Jr JA, Scherz HC, Kirsch AJ. Endoscopic Injection of dextranomer hyaluronic acid copolymer for the treatment of vesicoureteral reflux in duplex ureters. J Pediatr Urol, doi:10.1016/j.jpurol.2008.01.216.
  39. Elmore JM, Kirsch AJ, Heiss EA, Gilchrist A, Scherz HC. Incidence of Urinary Tract Infections in children after successful ureteral reimplantation versus endoscopic the dentranomer/hyaluronic acid implantation. J Urol. 2008;179(6):2364–2368

PII: S1477-5131(07)00480-9

doi: 10.1016/j.jpurol.2007.11.015

Journal of Pediatric Urology
Volume 4, Issue 3 , Pages 221-228 , June 2008

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