Journal of Pediatric Urology
Volume 3, Issue 6 , Pages 420-425 , December 2007

Can we prevent hypospadias?

Received 14 July 2007 ,Accepted 17 July 2007.

References 

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  8. Snodgrass W. Tubularized, incised plate urethroplasty for distal hypospadias. J Urol. 1994;51:464–465
  9. Baskin LS, Colborn T, Himes K. Hypospadias and endocrine disruption: is there a connection?. Environ Health Perspect. 2001;109:1175–1183
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  14. Willingham E, Baskin LS. Candidate genes and their response to environmental agents in the etiology of hypospadias. Nat Clin Pract Urol. 2007;4(5):270–279
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  16. Liu B, Wang Z, Lin G, Agras K, Ebbers M, Willingham E, et al. Activating transcription factor 3 is up-regulated in patients with hypospadias. Pediatr Res. 2005;58:1280–1283
  17. Liu B, Agras K, Willingham E, Vilela MLB, Baskin LS. Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation. Horm Res. 2006;65:217–222
  18. North K, Golding J. A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. BJU Int. 2000;85:107–113
  19. Kim KS, Torres CR, Yucel S, Raimondo K, Cunha GR, Baskin LS. Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environ Res. 2004;94:267–275
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  23. Blaschko SD, Willingham EJ, Baskin LS. Embryonic exposure to low-dose 17beta-estradiol decreases fetal mass sex specifically in male mice and does not cause hypospadias. J Investig Med. 2006;54(8):490–495
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☆ John Duckett Lecture presented at the European Society of Pediatric Urology, 27 April 2007, Brugge, Belgium.

PII: S1477-5131(07)00380-4

doi: 10.1016/j.jpurol.2007.07.007

Journal of Pediatric Urology
Volume 3, Issue 6 , Pages 420-425 , December 2007

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