Journal of Pediatric Urology
Volume 4, Issue 1 , Pages 55-59, February 2008

Differing urinary urea excretion among children with idiopathic hypercalciuria and/or hyperuricosuria

  • Cesare Polito

      Affiliations

    • Department of Pediatrics, Second University of Naples, Via L.De Crecchio, 2, 80138 Naples, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 081 5665413; fax: +39 081 5665427.
    • ,
  • Angela La Manna

      Affiliations

    • Department of Pediatrics, Second University of Naples, Via L.De Crecchio, 2, 80138 Naples, Italy
    • ,
  • Giuseppe Signoriello

      Affiliations

    • Department of Public Health, Second University of Naples, Naples, Italy
    • ,
  • Giuliana Lama

      Affiliations

    • Department of Pediatrics, Second University of Naples, Via L.De Crecchio, 2, 80138 Naples, Italy

Received 3 February 2007; accepted 12 April 2007. published online 06 June 2007.

Abstract 

Objective

To estimate dietary protein intake in children with idiopathic hypercalciuria (HC) and/or hyperuricosuria (HU).

Patients and methods

We compared the 24-h urinary excretion of urea, as a reflection of protein intake, in four age- and sex-matched groups, each comprising 56 consecutive children: (1) HC, (2) HU, (3) HC+HU and (4) control.

Results

Urinary urea excretion was significantly higher in HC, HU and HC+HU than in controls. HC and HU children had similar urea excretion. HC+HU children had urinary urea significantly higher than HC and HU, but urinary calcium similar to HC and urinary uric acid excretion similar to HU subjects. Urinary calcium was significantly (R2=0.21) correlated with urea excretion in HC children only, whereas urinary uric acid was significantly (R2=0.21) correlated with urinary urea in HU children only. No significant correlation between urinary urea and calcium or uric acid excretion was found in HC+HU patients although they had the highest urinary urea. A significant (p=0.004) interaction between urinary urea and sodium in increasing urinary calcium excretion resulted only in the HC group.

Conclusion

The association of dietary protein excess with HC and/or HU is conditioned by an individual (genetic?) predisposition and may be produced by different mechanisms.

Keywords: Hypercalciuria, Hyperuricosuria, Nephrolithiasis, Protein intake, Urinary urea

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PII: S1477-5131(07)00328-2

doi:10.1016/j.jpurol.2007.04.001

Journal of Pediatric Urology
Volume 4, Issue 1 , Pages 55-59, February 2008

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