Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 216-224 , August 2006

Timing of morphologic and apoptotic changes in the sheep fetal kidney in response to bladder outflow obstruction

  • Naeem Samnakay

      Affiliations

    • Department of Paediatric Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Western Australia, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 08 9340 8188; fax: +61 08 9340 8693.
    • ,
  • Jillian Orford

      Affiliations

    • Department of Paediatric Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Western Australia, Australia
    • Institute for Child Health Research, Roberts Road, Subiaco 6008, Western Australia, Australia
    • ,
  • Andrew Barker

      Affiliations

    • Department of Paediatric Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Western Australia, Australia
    • ,
  • Adrian Charles

      Affiliations

    • Department of Pathology, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Western Australia, Australia
    • ,
  • Philippa Terry

      Affiliations

    • Institute for Child Health Research, Roberts Road, Subiaco 6008, Western Australia, Australia
    • ,
  • John Newnham

      Affiliations

    • School of Women's and Infants' Health, University of Western Australia, Bagot Road, Subiaco 6008, Western Australia, Australia
    • ,
  • Timothy Moss

      Affiliations

    • School of Women's and Infants' Health, University of Western Australia, Bagot Road, Subiaco 6008, Western Australia, Australia

Received 23 September 2005 ,Accepted 24 May 2006.

References 

  1. Atwell JD. Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. J Pediatr Surg. 1983;18:70–74
  2. Casale AJ. Early ureteral surgery for posterior urethral valves. Urol Clin North Am. 1990;17:361–372
  3. Parkhouse HF, Barratt TM, Dillon MJ, Duffy PG, Fay J, Ransley PG, et al. Long-term outcome of boys with posterior urethral valves. Br J Urol. 1988;62:59–62
  4. Peters CA, Carr MC, Lais A, Retik AB, Mandell J. The response of the fetal kidney to obstruction. J Urol. 1992;148:503–509
  5. Gonzalez R, Reinberg Y, Burke B, Wells T, Vernier RL. Early bladder outlet obstruction in fetal lambs induces renal dysplasia and the prune-belly syndrome. J Pediatr Surg. 1990;25:342–345
  6. Beck AD. The effect of intra-uterine urinary obstruction upon the development of the fetal kidney. J Urol. 1971;105:784–789
  7. Potter E. Normal and abnormal development of the kidney. Chicago: Year Book Medical Publishers; 1972;
  8. Husain A, Pysher T, Dehner L. The kidney and lower urinary tract. 2nd ed.. Philadelphia: Lippincott Williams and Wilkins; 2001;
  9. Gobet R, Park JM, Nguyen HT, Chang B, Cisek LJ, Peters CA. Renal renin–angiotensin system dysregulation caused by partial bladder outlet obstruction in fetal sheep. Kidney Int. 1999;56:1654–1661
  10. Kim KM, Kogan BA, Massad CA. Acute hemodynamic and endocrinological effects of partial fetal bladder obstruction. J Urol. 1992;148:497–502
  11. Gobet R, Bleakley J, Cisek L, Kaefer M, Moses MA, Fernandez CA, et al. Fetal partial urethral obstruction causes renal fibrosis and is associated with proteolytic imbalance. J Urol. 1999;162:854–860
  12. Bogaert GA, Mevorach RA, Kogan BA. Renal hemodynamic and functional effects of 10 days' partial urinary obstruction in the fetal lamb. J Urol. 1994;152:220–225
  13. Kitagawa H, Pringle KC, Koike J, Zuccollo J, Seki Y, Fujiwaki S, et al. Optimal timing of prenatal treatment of obstructive uropathy in the fetal lamb. J Pediatr Surg. 2003;38:1785–1789
  14. Reed JC. Mechanisms of apoptosis. Am J Pathol. 2000;157:1415–1430
  15. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309–1312
  16. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322–1326
  17. Attar R, Quinn F, Winyard PJ, Mouriquand PD, Foxall P, Hanson MA, et al. Short-term urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal sheep kidneys. Am J Pathol. 1998;152:1225–1235
  18. Liapis H, Yu H, Steinhardt GF. Cell proliferation, apoptosis, Bcl-2 and Bax expression in obstructed opossum early metanephroi. J Urol. 2000;164:511–517
  19. Liapis H. Biology of congenital obstructive nephropathy. Nephron Exp Nephrol. 2003;93:e87–e91
  20. Doseff AI. Apoptosis: the sculptor of development. Stem Cells Dev. 2004;13:473–483
  21. Tarabishi R, Zahedi K, Mishra J, Ma Q, Kelly C, Tehrani K, et al. Induction of Zf9 in the kidney following early ischemia/reperfusion. Kidney Int. 2005;68:1511–1519
  22. Aravindan N, Shaw A. Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. Ren Fail. 2006;28:25–35
  23. Liapis H, Barent B, Steinhardt GF. Extracellular matrix in fetal kidney after experimental obstruction. J Urol. 2001;166:1433–1438
  24. Edouga D, Hugueny B, Gasser B, Bussieres L, Laborde K. Recovery after relief of fetal urinary obstruction: morphological, functional and molecular aspects. Am J Physiol Renal Physiol. 2001;281:F26–F37
  25. Porteous S, Torban E, Cho NP, Cunliffe H, Chua L, McNoe L, et al. Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/− mutant mice. Hum Mol Genet. 2000;9:1–11
  26. Aslan AR, Kogan BA. The effect of bladder outlet obstruction on the developing kidney. BJU Int. 2003;92:38–41
  27. Smith FG, Robillard JE. Pathophysiology of fetal renal disease. Semin Perinatol. 1989;13:305–319
  28. Lumbers ER. A brief review of fetal renal function. J Dev Physiol. 1984;6:1–10
  29. Duncomb GJ, Barker AP, Moss TJ, Gurrin LC, Charles AK, Smith NM, et al. The effects of overcoming experimental bladder outflow obstruction in fetal sheep. J Matern Fetal Neonatal Med. 2002;11:130–137

PII: S1477-5131(06)00101-X

doi: 10.1016/j.jpurol.2006.05.007

Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 216-224 , August 2006

Article Tools

* Image Usage & Resolution