Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 254-260 , August 2006

Experimental short-term partial fetal bladder outflow obstruction: II. Compliance and contractility associated with urinary flow impairment

  • M.K. Farrugia

      Affiliations

    • Institute of Child Health and Great Ormond Street Hospital, University College London, London, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 7951 968757; fax: +44 2079 052133.
    • ,
  • M.L. Godley

      Affiliations

    • Institute of Child Health and Great Ormond Street Hospital, University College London, London, UK
    • ,
  • A.S. Woolf

      Affiliations

    • Institute of Child Health and Great Ormond Street Hospital, University College London, London, UK
    • ,
  • D.M. Peebles

      Affiliations

    • Department of Obstetrics and Gynaecology, University College London, London, UK
    • ,
  • P.M. Cuckow

      Affiliations

    • Institute of Child Health and Great Ormond Street Hospital, University College London, London, UK
    • ,
  • C.H. Fry

      Affiliations

    • Institute of Urology and Nephrology, University College London, London, UK

Received 18 October 2005 ,Accepted 15 February 2006.

References 

  1. Hendren WH. Posterior urethral valves in boys. A broad clinical spectrum. J Urol. 1971;106:298–307
  2. Ghanem MA, Wolffenbuttel KP, De Vylder A, Nijman RJ. Long-term bladder dysfunction and renal function in boys with posterior urethral valves based on urodynamic findings. J Urol. 2004;171:2409–2412
  3. Clark TJ, Martin WL, Divakaran TG, Whittle MJ, Kilby MD, Khan KS. Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. Obstet Gynecol. 2003;102:367–382
  4. Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJ, Peebles DM, et al. Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. J Urol. 2002;168:1615–1620
  5. Thiruchelvam N, Wu C, David A, Woolf AS, Cuckow PM, Fry CH. Neurotransmission and viscoelasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol. 2003;284:R1296–R1305
  6. Thiruchelvam N, Nyirady P, Peebles DM, Fry CH, Cuckow PM, Woolf AS. Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder. Am J Pathol. 2003;162:1271–1282
  7. Farrugia M-K, Long DA, Godley ML, Peebles DM, Fry CH, Cuckow PM, et al. Experimental short-term partial obstruction of the fetal sheep bladder outflow. I Morphology and cell biology assoicated with urinary flow impairment. J Paediatr Urol, in this issue.
  8. Rohrmann D, Zderic SA, Duckett JW, Levin RM, Damaser MS. Compliance of the obstructed fetal rabbit bladder. Neurourol Urodyn. 1997;16:179–189
  9. Beck AD. The effect of intra-uterine urinary obstruction upon the development of the fetal kidney. J Urol. 1971;105:784–789
  10. Harrison MR, Ross N, Noall R, de Lorimier AA. Correction of congenital hydronephrosis in utero. I. The model: fetal urethral obstruction produces hydronephrosis and pulmonary hypoplasia in fetal lambs. J Pediatr Surg. 1983;18:247–256
  11. Attar R, Quinn F, Winyard PJ, Mouriquand PD, Foxall P, Hanson MA, et al. Short-term urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal sheep kidneys. Am J Pathol. 1998;152:1225–1235
  12. Bogaert GA, Gluckman GR, Mevorach RA, Kogan BA. Renal preservation despite 35 days of partial bladder obstruction in the fetal lamb. J Urol. 1995;154:694–699
  13. Gobet R, Bleakley J, Cisek L, Kaefer M, Moses MA, Fernandez CA, et al. Fetal partial urethral obstruction causes renal fibrosis and is associated with proteolytic imbalance. J Urol. 1999;162:854–860
  14. Peters CA, Vasavada S, Dator D, Carr M, Shapiro E, Lepor H, et al. The effect of obstruction on the developing bladder. J Urol. 1992;148:491–496
  15. Gobet R, Bleakley J, Peters CA. Premature urachal closure induces hydroureteronephrosis in male fetuses. J Urol. 1998;160:1463–1467
  16. de Tayrac R, Cuckow PM, Devlieger R, Deprest J, Bogaert G, Ville Y. Antenatal urodynamic studies in the fetal lamb: experimental protocol and preliminary results. Prenat Diagn. 2003;23:187–192
  17. Thiruchelvam N, Godley ML, Farrugia MK, Cuckow PM. A preliminary study of natural-fill radiotelemetered ovine fetal cystometry. BJU Int. 2004;93:382–387
  18. Edouga D, Hugueny B, Gasser B, Bussieres L, Laborde K. Recovery after relief of fetal urinary obstruction: morphological, functional and molecular aspects. Am J Physiol. 2001;281:F26–F37
  19. Sato Y, Kitagawa H, Pringle KC, Koike J, Zuccollo J, Robinson R, et al. Effects of early vesicostomy in obstructive uropathy on bladder development. J Pediatr Surg. 2004;39:1849–1852

PII: S1477-5131(06)00046-5

doi: 10.1016/j.jpurol.2006.02.006

Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 254-260 , August 2006

Article Tools

* Image Usage & Resolution