Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 243-253 , August 2006

Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment

  • M.-K. Farrugia

      Affiliations

    • Nephro-Urology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 20 7905 2651; fax: +44 20 7905 2133.
    • ,
  • D.A. Long

      Affiliations

    • Nephro-Urology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, UK
    • ,
  • M.L. Godley

      Affiliations

    • Nephro-Urology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, UK
    • ,
  • D.M. Peebles

      Affiliations

    • Department of Obstetrics and Gynaecology, University College London, London, UK
    • ,
  • C.H. Fry

      Affiliations

    • Institute of Urology and Nephrology, University College London, London, UK
    • ,
  • P.M. Cuckow

      Affiliations

    • Nephro-Urology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, UK
    • ,
  • A.S. Woolf

      Affiliations

    • Nephro-Urology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, UK

Received 14 October 2005 ,Accepted 9 January 2006.

References 

  1. Woolf AS, Thiruchelvam N. Congenital obstructive uropathy – its origin and contribution to end-stage renal failure in children. Adv Ren Replace Ther. 2001;8:157–163
  2. Woolf AS, Welham SJ, Hermanns M, Winyard PJ. Maldevelopment of the human kidney and lower urinary tract: an overview. In:  Vize PD,  Woolf AS,  Bard JBL editor. The kidney: from normal development to congenital disease. Elsevier Science/Academic Press; 2003;p. 377–393[Chapter 21]
  3. Glassberg KI. The valve bladder: 20 years later. J Urol. 2001;166:1406–1414
  4. Parkhouse HF, Barratt TM, Dillon MJ, Duffy PG, Fay J, Ransley PG, et al. Long-term outcome of boys with posterior urethral valves. Br J Urol. 1988;62:59–62
  5. Clark TJ, Martin WL, Divakaran TG, Whittle MJ, Kilby MD, Khan KS. Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. Obstet Gynecol. 2003;102:367–382
  6. Peters CA, Vasavada S, Dator D, Carr M, Shapiro E, Lepor H, et al. The effect of obstruction on the developing bladder. J Urol. 1992;148:491–496
  7. Peters CA, Carr MC, Lais A, Retik AB, Madell J. The response of the fetal kidney to obstruction. J Urol. 1992;148:503–509
  8. Attar R, Quinn F, Winyard PJ, Mouriquand PD, Foxall P, Hanson MA, et al. Short-term urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal sheep kidneys. Am J Pathol. 1998;152:1225–1235
  9. Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJ, Peebles DM, et al. Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. J Urol. 2002;168:1615–1620
  10. Thiruchelvam N, Nyirady P, Peebles DM, Fry CH, Cuckow PM, Woolf AS. Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder. Am J Pathol. 2003;162:1271–1282
  11. Thiruchelvam N, Wu C, David A, Woolf AS, Cuckow PM, Fry CH. Neurotransmission and viscoelasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol Regul Integr Comp Physiol. 2003;284:R1296–R1305
  12. Shimada K, Hosokawa S, Tohda A, Matsumoto F, Johnin K. Histology of the fetal prune belly syndrome with reference to decompression. Int J Urol. 2000;7:161–166
  13. Farrugia MK, Godley ML, Woolf AS, Peebles DM, Cuckow PM, and CH Fry. Experimental short-term fetal bladder outflow obstruction: II. Compliance and contractility associated with urinary flow impairment. J Pediatr Urol, in press.
  14. Lye SJ, Freitag CL, Challis JR. Ovine fetal urachus – physiological and hormonal control of its contractile activity. Am J Physiol. 1988;254:F25–F31
  15. Harrison MR, Ross N, Noall R, de Lorimer AA. Correction of congenital hydronephrosis in utero. I. The model: fetal urethral obstruction produces hydronephrosis and pulmonary hypoplasia in lambs. J Pediatr Surg. 1983;18:247–256
  16. Gobet R, Bleakley J, Peters CA. Premature urachal closure induces hydroureteronephrosis in male fetuses. J Urol. 1998;160:1463–1467
  17. Freedman AL, Qureshi F, Shapiro E, Lepor H, Jacques SM, Evans MI, et al. Smooth muscle development in the obstructed fetal bladder. Urology. 1997;49:104–109
  18. Romih R, Korosec P, Jezernik K, Sedmak B, Trsinar B, Deng F-M, et al. Inverse expression of uroplakins and inducible nitric oxide synthase in the urothelium of patients with bladder outlet obstruction. BJU Int. 2003;91:507–512
  19. Jezernik K, Romih R, Mannherz HG, Koprivec D. Immunohistochemical detection of apoptosis, proliferation and inducible nitric oxide synthase in rat urothelium damaged by cyclophosphamide treatment. Cell Biol Int. 2003;27:863–869
  20. Appodaca G. The urothelium: not just a passive barrier. Traffic. 2005;5:117–128

PII: S1477-5131(06)00028-3

doi: 10.1016/j.jpurol.2006.01.019

Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 243-253 , August 2006

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