Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 271-276 , August 2006

Intravesical pressure induces hyperplasia and hypertrophy of human bladder smooth muscle cells mediated by muscarinic receptors

  • Sang Don Lee

      Affiliations

    • College of Medicine, Pusan National University, Busan, Republic of Korea
    • ,
  • Cem Akbal

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University, IN, USA
    • ,
  • Chaeyong Jung

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University, IN, USA
    • ,
  • Martin Kaefer

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University, IN, USA
    • Corresponding Author InformationCorresponding author. Department of Pediatric Urology, Riley Hospital for Children, Indiana University, 702 Barnhill Drive, Indianapolis, IN 46202, USA. Tel.: +1 317 274 8896; fax: +1 317 274 7481.

Received 17 October 2005 ,Accepted 8 November 2005.

References 

  1. Edelstein RA, Bauer SB, Kelly MD, Darbey MM, Peter CA, Atala A, et al. The long-term urological response of neonates with myelodysplasia treated proactively with intermittent catheterization and anticholinergic therapy. J Urol. 1995;154:1500
  2. Gobet R, Bleakley J, Cisek L, Kaefer M, Moses MA, Fernandez CA, et al. Fetal partial ureteral obstruction causes renal fibrosis and is associated with proteolytic imbalance. J Urol. 1999;162:854
  3. Backhaus BO, Kaefer M, Haberstroh KM, Hile K, Nagatomi J, Rink RC, et al. Alterations in the molecular determinants of bladder compliance at hydrostatic pressures less than 40cmH2O. J Urol. 2002;168:2600
  4. Guizzetti M, Costa P, Peters J, Costa LG. Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Eur J Pharmacol. 1996;297:265
  5. Metzen J, Bittinger F, Kirkpatrick CJ, Kilbinger H, Wessler I. Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype. Science. 2003;72:2075
  6. Haberstroh KM, Kaefer M, Retik AB, Freeman MR, Bizios R. The effects of sustained hydrostatic pressure on select bladder smooth muscle cell functions. J Urol. 1999;162:2114
  7. Lee SD, Misseri R, Akbal C, Jung C, Rink RC, Kaefer M. Muscarinic receptor expression increases following exposures to intravesical pressure of ≤40cmH2O. J Urol. 2005;173:191;[abstract 702]

PII: S1477-5131(06)00019-2

doi: 10.1016/j.jpurol.2005.11.015

Journal of Pediatric Urology
Volume 2, Issue 4 , Pages 271-276 , August 2006

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