Journal of Pediatric Urology
Volume 2, Issue 5 , Pages 402-408 , October 2006

Upregulation of both PDGF-BB and PDGF-BB receptor in human bladder fibroblasts in response to physiologic hydrostatic pressure

  • Cem Akbal

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University School of Medicine, Indiana, USA
    • Supported by the Scientific and Technical Research Council of Turkey.
    • ,
  • Sang Don Lee

      Affiliations

    • College of Medicine, Pusan National University, Busan, Korea
    • ,
  • Chaeyong Jung

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University School of Medicine, Indiana, USA
    • ,
  • Richard Rink

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University School of Medicine, Indiana, USA
    • ,
  • Martin Kaefer

      Affiliations

    • Department of Urology, Riley Hospital for Children, Indiana University School of Medicine, Indiana, USA
    • Corresponding Author InformationCorresponding author. Department of Urology, Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive #1739, Indianapolis, IN 46202, USA. Tel.: +1 317 274 889; fax: +1 317 274 7481.

Received 19 January 2005 ,Accepted 18 August 2005.

References 

  1. Bonner JC. Regulation of PDGF and its receptors in fibrotic disease. Cytokine Growth Factor Rev. 2004;15:255–273
  2. Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283–1316
  3. Stehr M, Adam RM, Khoury J, Zhuang L, Solomon KR, Peters CA, et al. Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J Urol. 2003;169:1165–1170
  4. Kaefer M, Barnewolt C, Retik AB, Peters CA. The sonographic diagnosis of infravesical obstruction in children: evaluation of bladder wall thickness indexed to bladder filling. J Urol. 1997;157:989–991
  5. Ghafar MA, Anastasiadis AG, Olsson LE, Chichester P, Kaplan SA, Buttyan R, et al. Hypoxia and an angiogenic response in the partially obstructed rat bladder. Lab Invest. 2002;82:903–909
  6. Backhaus BO, Kaefer M, Haberstroh KM, Hile K, Nagatomi J, Rink RC, et al. Alterations in the molecular determinants of bladder compliance at hydrostatic pressures less than 40cm H2O. J Urol. 2002;168:2600–2604
  7. Park JM, Borer JG, Freeman MR, Peters CA. Stretch activates heparin binding EGF-like growth factor expression in bladder smooth muscle cells. Am J Physiol. 1998;275:C1247–C1254
  8. Shaw MBK, Jung C, Cain MP, Casale AJ, Rink RC, Kaefer M. Heparin-binding epidermal growth factor-like growth factor induces hypertrophy in human bladder smooth muscle cells. XIVth ESPU Madrid, Spain, 12–15 March. BJU Int. 2003;91:
  9. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974;71:1207–1210
  10. Raines EW. PDGF and cardiovascular disease. Cytokine Growth Factor Rev. 2004;15:237–254
  11. Oh SJ, Kurtz H, Christ B, Wilting J. Platelet-derived growth factor B induces transformation of fibrocytes into spindle shaped myofibroblast in vivo. Histochem Cell Biol. 1998;109:349–357
  12. Buoro S, Ferrarese P, Chiavegato A, Roelofs M, Scatena M, Pauletto P, et al. Myofibroblast-derived smooth muscle cells during remodeling of rabbit urinary bladder wall induced by partial outflow obstruction. Lab Invest. 1993;69:589–602
  13. Levitzki A. PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases. Cytokine Growth Factor Rev. 2004;15:229–235

☆ Supported by grants from the Showwalter foundation, Robert Garrett professorship and Riley Memorial Foundation, Indiana University.

PII: S1477-5131(05)00143-9

doi: 10.1016/j.jpurol.2005.08.004

Journal of Pediatric Urology
Volume 2, Issue 5 , Pages 402-408 , October 2006

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