Journal of Pediatric Urology
Volume 1, Issue 1 , Pages 11-25 , February 2005

Testicular descent, cryptorchidism and inguinal hernia: the Melbourne perspective

  • Hideki Tomiyama

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Yasunari Sasaki

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Jenny Huynh

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Eric Yong

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Alvin Ting

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • John M. Hutson

      Affiliations

    • F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Australia
    • Department of General Surgery, Royal Children's Hospital, Victoria, Australia
    • Department of Paediatrics, University of Melbourne, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia. Tel.: +61 3 9345 5805; fax: +61 3 9345 7997.

Received 7 September 2004

References 

  1. James EG. Disorders of the testes and the male reproductive tract. 9th ed.. Philadelphia: WB Saunders; 1998;
  2. Elder JS. The undescended testis. Hormonal and surgical management. Surg Clin North Am. 1998;68:983–1005
  3. Jirasek JE. Morphogenesis of the genital system in the human. Birth Defect Orig Artic Ser. 1997;13:13–39
  4. Imperato-McGinley J, Peterson RE. Male pseudohermaphroditism: the complexities of male phenotypic development. Am J Med. 1976;61:251–272
  5. Saenger P. Abnormal sexual differentiation. J Pediatr. 1984;104:1–14
  6. Migeon CJ, Berkovitz GD, Brown TR, et al. The diagnosis and treatment of endocrine disorders in childhood and adolescence. 4th ed.. Springfield: CC Thomas; 1994;
  7. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature. 1990;346:240–244
  8. Larsen WJ. Human embryology. London: Churchill Livingstone; 1993;
  9. O'Rahilly R. The development of the vagina in the human. Birth Defect Orig Artic Ser. 1977;13:123–136
  10. Josso N, Picard JY, Tran D. The anti-Mullerian hormone. Birth Defect Orig Artic Ser. 1977;13:59–84
  11. Behringer RR, Finegold MJ, Cate RL. Mullerian-inhibiting substance function during mammalian sexual development. Cell. 1994;79:415–425
  12. Winter JS, Faiman C, Reyes FI. Sex steroid production by the human fetus: its role in morphogenesis and control by gonadotropins. Birth Defect Orig Artic Ser. 1977;13:41–58
  13. Tong SY, Hutson JM, Watts LM. Does testosterone diffuse down the Wolffian duct during sexual differentiation?. J Urol. 1996;155:2057–2059
  14. Ivell R. Biology of the relaxin-like factor (RLF). Rev Reprod. 1997;2:133–138
  15. Grumbach MM, Ducharme JR. The effects of androgens on fetal sexual development. Fertil Steril. 1960;1786(11):157–180
  16. Hunter JA. Description of the situation of the testis in the foetus with its descent into the scrotum. London.
  17. Heyns CF. The gubernaculum during testicular descent in the human fetus. J Anat. 1987;153:93–112
  18. Heyns CF, Human HJ, Werely CJ, et al. The glycosaminoglycans of the gubernaculum during testicular descent in the fetus. J Urol. 1990;143:612–617
  19. Tanyel FC, Muftuoglu S, Dagdeviren A, et al. Myofibroblasts defined by electron microscopy suggest the dedifferentiation of smooth muscle within the sac walls associated with congenital inguinal hernia. BJU Int. 2001;87:251–255
  20. Hutson JM, Hasthorpe S, Heyns CF. Anatomical and functional aspects of testicular descent and cryptorchidism. Endocr Rev. 1997;18:259–280
  21. van der Schoot P. The name cranial ovarian suspensory ligaments in mammalian anatomy should be used only to indicate the structures derived from the foetal cranial mesonephric and gonadal ligaments. Anat Rec. 1993;237:434–438
  22. Backhouse KM. The natural history of testicular descent and maldescent. Proc R Soc Med. 1966;59:357–360
  23. Shrock P. The processus vaginalis and gubernaculum. Their raison d'etre redefined. Surg Clin North Am. 1971;51:1263–1268
  24. Gier HM, Marion GB. Development of mammalian testes and genital ducts. Biol Reprod. 1969;1:1–23
  25. Ramasamy M, Di Pilla N, Yap T, et al. Enlargement of the processus vaginalis during testicular descent in rats. Pediatr Surg Int. 2001;17:312–315
  26. Tanyel FC, Dagdeviren A, Muftuoglu S, et al. Inguinal hernia revisited through comparative evaluation of peritoneum, processus vaginalis, and sacs obtained from children with hernia, hydrocele, and undescended testis. J Pediatr Surg. 1999;34:552–555
  27. Tanyel FC, Sara Y, Ertunc M, et al. Lack of carbachol response indicates the absence of cholinergic receptors in sacs associated with undescended testis. J Pediatr Surg. 1999;34:1339–1344
  28. Tanyel FC, Talim B, Kale G, et al. A reevaluation of the structures accepted to represent the postnatal gubernaculum. Urol Int. 2002;69:116–119
  29. Leese G, Hopwood D. Muscle fibre typing in the human pharyngeal constrictors and oesophagus: the effect of ageing. Acta Anat (Basel). 1986;127:77–80
  30. Quinlan DM, Gearhart JP, Jeffs RD. Abdominal wall defects and cryptorchidism: an animal model. J Urol. 1988;140:1141–1144
  31. Frey HL, Peng S, Rajfer J. Synergy of abdominal pressure and androgens in testicular descent. Biol Reprod. 1983;29:1233–1239
  32. Frey HL, Rajfer J. Role of the gubernaculum and intraabdominal pressure in the process of testicular descent. J Urol. 1984;131:574–579
  33. Hutson JM, Terada M, Zhou B, et al. Normal testicular descent and the aetiology of cryptorchidism. Adv Anat Embryol Cell Biol. 1996;132:1–56
  34. Hutson JM. A biphasic model for the hormonal control of testicular descent. Lancet. 1985;2:419–421
  35. Hutson JM, Donahoe PK. The hormonal control of testicular descent. Endocr Rev. 1986;7:270–283
  36. Kubota Y, Nef S, Farmer PJ, et al. Leydig insulin-like hormone, gubernacular development and testicular descent. J Urol. 2001;165:1673–1675
  37. Nef S, Parada LF. Cryptorchidism in mice mutant for INSL3. Nat Genet. 1999;22:295–299
  38. Hutson JM. Exogenous oestrogens prevent transabdominal, testicular descent in mice with complete androgen resistance (testicular feminisation). Pediatr Surg Int. 1987;2:242–246
  39. Hutson JM, Beasley SW. The mechanisms of testicular descent. Aust Paediatr J. 1987;23:215–216
  40. Wensing CJ. Testicular descent in the rat and a comparison of this process in the rat with that in the pig. Anat Rec. 1986;214:154–160
  41. Elder JS, Isaacs JT, Walsh PC. Androgenic sensitivity of the gubernaculum testis: evidence for hormonal/mechanical interactions in testicular descent. J Urol. 1982;127:170–176
  42. Radhakrishnan J, Morikawa Y, Donahoe PK, et al. Observations on the gubernaculum during descent of the testis. Invest Urol. 1979;16:365–368
  43. van der Schoot P, Elger W. Perinatal development of gubernacular cones in rats and rabbits: effect of exposure to anti-androgens. Anat Rec. 1993;236:399–407
  44. Lam SK, Clarnette TD, Hutson JM. Does the gubernaculum migrate during inguinoscrotal testicular descent in the rat?. Anat Rec. 1998;250:159–163
  45. Lee MM, Donahoe PK. Mullerian inhibiting substance: a gonadal hormone with multiple functions. Endocr Rev. 1993;14:152–164
  46. Josso N, Cate RL, Picard JY, et al. Anti-mullerian hormone: the Jost factor. Recent Prog Horm Res. 1993;48:1–59
  47. Bashir MS, Wells M. Mullerian inhibiting substance. J Pathol. 1995;176:109–110
  48. Cohen-Haguenauer O, Picard JY, Mattei MG, et al. Mapping of the gene for anti-mullerian hormone to the short arm of human chromosome 19. Cytogenet Cell Genet. 1987;44:2–6
  49. Baker ML, Metcalfe SA, Hutson JM. Serum levels of Mullerian inhibiting substance in boys from birth to 18 years, as determined by enzyme immunoassay. J Clin Endocrinol Metab. 1990;70:11–15
  50. Yamanaka J, Baker M, Metcalfe S, Hutson JM. Serum levels of Mullerian inhibiting substance in boys with cryptorchidism. J Pediatr Surg. 1991;26:621–623
  51. Zhou B, Watts LM, Hutson JM. Germ cell development in neonatal mouse testes in vitro requires Mullerian inhibiting substance. J Urol. 1993;150:613–616
  52. Charpentier G, Magre S. Masculinizing effect of testes on developing rat ovaries in organ culture. Development. 1990;110:839–849
  53. Catlin EA, MacLaughlin DT, Donahoe PK. Mullerian inhibiting substance: new perspectives and future directions. Microsc Res Tech. 1993;25:121–133
  54. Josso N, Fekete C, Cachin O, et al. Persistence of Mullerian ducts in male pseudohermaphroditism, and its relationship to cryptorchidism. Clin Endocrinol (Oxf). 1983;19:247–258
  55. Hutson JM, Chow CW, WDN . Persistent Mullerian duct syndrome with transverse testicular ectopia. Pediatr Surg Int. 1987;2:191–194
  56. Hutson JM, Davidson PM, Reece LA, et al. Failure of gubernacular development in the persistent Mullerian duct syndrome allows herniation of the testes. Pediatr Surg Int. 1994;9:544–546
  57. Hutson JM, Baker M. A hypothesis to explain abnormal descent in persistent Mullerian duct syndrome. Pediatr Surg Int. 1994;9:542–543
  58. Josso N, Picard JY, Imbeaud S, et al. Clinical aspects and molecular genetics of the persistent Mullerian duct syndrome. Clin Endocrinol (Oxf). 1997;47:137–144
  59. Guerrier D, Tran D, Vanderwinden JM, et al. The persistent Mullerian duct syndrome: a molecular approach. J Clin Endocrinol Metab. 1989;68:46–52
  60. Tran D, Picard JY, Vigier B, et al. Persistence of Mullerian ducts in male rabbits passively immunized against bovine anti-Mullerian hormone during fetal life. Dev Biol. 1986;116:160–167
  61. Fentener van Vlissingen JM, van Zoelen EJ, Ursem PJ, et al. In vitro model of the first phase of testicular descent: identification of a low molecular weight factor from fetal testis involved in proliferation of gubernaculum testis cells and distinct from specified polypeptide growth factors and fetal gonadal hormones. Endocrinology. 1988;123:2868–2877
  62. Bartlett JE, Lee SM, Mishina Y, et al. Gubernacular development in Mullerian inhibiting substance receptor-deficient mice. BJU Int. 2002;89:113–118
  63. Mishina Y, Rey R, Finegold MJ, et al. Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev. 1996;10:2577–2587
  64. Lane AH, Donahoe PK. New insights into Mullerian inhibiting substance and its mechanism of action. J Endocrinol. 1998;158:1–6
  65. Adham IM, Burkhardt E, Benahmed M, et al. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J Biol Chem. 1993;268:26668–26672
  66. Burkhardt E, Adham IM, Hobohm U, et al. A human cDNA coding for the Leydig insulin-like peptide (Ley I-L). Hum Genet. 1994;94:91–94
  67. Zimmermann S, Steding G, Emmen JM, et al. Targeted disruption of the INSL3 gene causes bilateral cryptorchidism. Mol Endocrinol. 1999;13:681–691
  68. Zimmermann S, Schottler P, Engel W, et al. Mouse Leydig insulin-like (Ley I-L) gene. Structure and expression during testis and ovary development. Mol Reprod Dev. 1997;47:30–38
  69. Zimmermann S, Schwarzler A, Buth S, et al. Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1. Mol Endocrinol. 1998;12:706–713
  70. Bullesbach EE, Schwabe C. A novel Leydig cell cDNA-derived protein is a relaxin-like factor. J Biol Chem. 1995;270:16011–16015
  71. Emmen JM, McLuskey A, Adham IM, et al. Involvement of insulin-like factor 3 (INSL3) in diethylstilbestrol-induced cryptorchidism. Endocrinology. 2000;141:846–849
  72. Tomboc M, Lee PA, Mitwally MF, et al. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. J Clin Endocrinol Metab. 2000;85:4013–4018
  73. Krausz C, Quintana-Murci L, Fellous M, et al. Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism. Mol Hum Reprod. 2000;6:298–302
  74. Hsu SY, Nakabayashi K, Nishi S, et al. Activation of orphan receptors by the hormone relaxin. Science. 2002;295:671–674
  75. Kubota Y, Temelcos C, Bathgate RA, et al. The role of insulin 3, testosterone, Mullerian inhibiting substance and relaxin in rat gubernacular growth. Mol Hum Reprod. 2002;8:900–905
  76. Fu P, Layfield S, Ferraro T, et al. Synthesis, conformation, receptor binding and biological activities of monobiotinylated human insulin-like peptide 3. J Pept Res. 2004;63:91–98
  77. Overbeek PA, Gorlov IP, Sutherland RW, et al. A transgenic insertion causing cryptorchidism in mice. Genesis. 2001;30:26–35
  78. Gorlov IP, Kamat A, Bogatcheva NV, et al. Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet. 2002;11:2309–2318
  79. Tomiyama H, Hutson JM, Truong A, et al. Transabdominal testicular descent is disrupted in mice with deletion of insulin like factor 3 receptor. J Pediatr Surg. 2003;38:1793–1798
  80. Cain MP, Kramer SA, Tindall DJ, et al. Flutamide-induced cryptorchidism in the rat is associated with altered gubernacular morphology. Urology. 1995;46:553–558
  81. Husmann DA, McPhaul MJ. Time-specific androgen blockade with flutamide inhibits testicular descent in the rat. Endocrinology. 1991;129:1409–1416
  82. Heyns CF, Pape VC. Presence of a low capacity androgen receptor in the gubernaculum of the pig fetus. J Urol. 1991;145:161–167
  83. Lewis LG. Cryptorchidism. J Urol. 1948;60:345–356
  84. Beasley SW, Hutson JM. Effect of division of genitofemoral nerve on testicular descent in the rat. Aust N Z J Surg. 1987;57:49–51
  85. Fallat ME, Williams MPL, Farmer PJ, et al. Histologic evaluation of inguinoscrotal migration of the gubernaculum in rodents during testicular descent and its relationship to the genitofemoral nerve. Pediatr Surg Int. 1992;7:265–270
  86. Tayakkanonta K. The gubernaculum testis and its nerve supply. Aust N Z J Surg. 1963;33:63
  87. Goh DW, Middlesworth W, Farmer PJ, et al. Prenatal androgen blockade with flutamide inhibits masculinization of the genitofemoral nerve and testicular descent. J Pediatr Surg. 1994;29:836–838
  88. Larkins SL, Williams MPL, Hutson JM. Localization of calcitonin gene-related peptide within the spinal nucleus of the genitofemoral nerve. Pediatr Surg Int. 1991;6:176–179
  89. Goh DW, Farmer PJ, Hutson JM. Absence of normal sexual dimorphism of the genitofemoral nerve spinal nucleus in the mutant cryptorchid (TS) rat. J Reprod Fertil. 1994;102:195–199
  90. Amara SG, Jonas V, Rosenfeld MG, et al. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 1982;298:240–244
  91. Rosenfeld MG, Mermod JJ, Amara SG, et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature. 1983;304:129–135
  92. Tache Y, Holzer P, Rosenfeld MG. Calcitonin gene-related peptide. The first decade of a novel pleiotropic neuropeptide. Ann N Y Acad Sci. 1992;657:1–561
  93. Gibson SJ, Polak JM, Bloom SR, et al. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci. 1984;4:3101–3111
  94. New HV, Mudge AW. Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. Nature. 1986;323:809–811
  95. Sigrist S, Franco-Cereceda A, Muff R, et al. Specific receptor and cardiovascular effects of calcitonin gene-related peptide. Endocrinology. 1986;119:381–389
  96. Santicioli P, Maggi CA, Geppetti P, et al. Release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from organs of the genitourinary tract in rats. Neurosci Lett. 1988;92:197–201
  97. Barthold JS, Mahler HR, Newton BW. Lack of feminization of the cremaster nucleus in cryptorchid androgen insensitive rats. J Urol. 1994;152:2280–2286
  98. Barthold JS, Mahler HR, Sziszak TJ, et al. Lack of feminization of the cremaster nucleus by prenatal flutamide administration in the rat and pig. J Urol. 1996;156:767–771
  99. Hrabovszky Z, Farmer PJ, Hutson JM. Does the sensory nucleus of the genitofemoral nerve have a role in testicular descent?. J Pediatr Surg. 2000;35:96–100
  100. Park WH, Hutson JM. The gubernaculum shows rhythmic contractility and active movement during testicular descent. J Pediatr Surg. 1991;26:615–617
  101. Momose Y, Griffiths AL, Hutson JM. Testicular descent. III. The neonatal mouse gubernaculum shows rhythmic contraction in organ culture in response to calcitonin gene-related peptide. Endocrinology. 1992;131:2881–2884
  102. Yamanaka J, Metcalfe SA, Hutson JM, et al. Testicular descent. II. Ontogeny and response to denervation of calcitonin gene-related peptide receptors in neonatal rat gubernaculum. Endocrinology. 1993;132:280–284
  103. Terada M, Hutson JM, Watts LM. Characterization of the gubernacular contractile response to calcitonin gene-related peptide in the mouse. J Pediatr Surg. 1995;30:730–733
  104. Terada M, Hutson JM, Farmer PJ, et al. The role of the genitofemoral nerve and calcitonin gene-related peptide in congenitally cryptorchid mutant TS rats. J Urol. 1995;154:734–737
  105. Momose Y, Goh DW, Hutson JM. Calcitonin gene-related peptide stimulates motility of the gubernaculum via cyclic adenosine monophosphate. J Urol. 1993;150:571–573
  106. Terada M, Goh DW, Farmer PJ, et al. Ontogeny of gubernacular contraction and effect of calcitonin gene-related peptide in the mouse. J Pediatr Surg. 1994;29:609–611
  107. Husmann DA, Levy JB. Current concepts in the pathophysiology of testicular undescent. Urology. 1995;46:267–276
  108. Tanyel FC, Ertunc M, Buyukpamukcu N, et al. Mechanisms involved in contractile differences among cremaster muscles according to localization of tests. J Pediatr Surg. 2001;36:1551–1560
  109. Ng SL, Bidarklar SS, Sourial M, et al., Gubernacular cell division in different rodent models of cryptorchidism support indirect androgenergic action via the genitofemoral nerve. J Pediatr Surg, in press.
  110. Tanyel FC, Kale G. Evaluation of mystery of the hernia sac through another perspective. Pediatr Dev Pathol. 2001;4:512–515
  111. Tanyel FC, Ulusu NN, Tezcan EF, et al. Total calcium content of sacs associated with inguinal hernia, hydrocele or undescended testis reflects differences dictated by programmed cell death. Urol Int. 2003;70:211–215
  112. Tomiyama H, Hutson JM. Contractility of rat gubernacula affected by CGRP and beta agonist. J Pediatr Surg, in press.
  113. Clarnette TD, Rowe D, Hasthorpe S, et al. Incomplete disappearance of the processus vaginalis as a cause of ascending testis. J Urol. 1997;157:1889–1891
  114. Smith JA, Hutson JM, Beasley SW, et al. The relationship between cerebral palsy and cryptorchidism. J Pediatr Surg. 1989;24:1303–1305
  115. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?. Lancet. 1993;29:1392–1395
  116. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–978
  117. Skakkebaek NE, Rajpert-De Meyts E, Jorgensen N, et al. Germ cell cancer and disorders of spermatogenesis: an environmental connection?. APMIS. 1998;106:3–12
  118. Mengel W, Hienz HA, Sippe WG, et al. Studies on cryptorchidism: a comparison of histological findings in the germinative epithelium before and after the second year of life. J Pediatr Surg. 1974;9:445–450
  119. Hadziselimovic F, Herzog B, Seguchi H. Surgical correction of cryptorchism at 2 years: electron microscopic and morphometric investigations. J Pediatr Surg. 1975;10:19–26
  120. Hadziselimovic F. Fertility and cryptorchidism. Am J Dis Child. 1985;139:963–964
  121. Huff DS, Hadziselimovic F, Snyder HM, et al. Postnatal testicular maldevelopment in unilateral cryptorchidism. J Urol. 1989;142:546–548
  122. Huff DS, Hadziselimovic F, Snyder HM, et al. Early postnatal testicular maldevelopment in cryptorchidism. J Urol. 1991;146:624–626
  123. Huff DS, Hadziselimovic F, Snyder HM, et al. Histologic maldevelopment of unilaterally cryptorchid testes and their descended partners. Eur J Pediatr. 1993;152(Suppl. 2):S11–S14
  124. Skakkebaek NE, Berthelsen JG, Giwercman A, et al. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl. 1987;10:19–28
  125. Mieusset R, Fouda PJ, Vaysse P, et al. Increase in testicular temperature in case of cryptorchidism in boys. Fertil Steril. 1993;59:1319–1321
  126. Tapanainen JS, Tilly JL, Vihko KK, et al. Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol. 1993;7:643–650
  127. Billig H, Furuta I, Rivier C, Tapanainen J, et al. Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology. 1995;136:5–12
  128. Mieusset R, Bujan L. Testicular heating and its possible contributions to male infertility: a review. Int J Androl. 1995;18:169–184
  129. Nakai A, Suzuki M, Tanabe M. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J. 2000;19:1545–1554
  130. Huckins C. The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of the germinal epithelium. Anat Rec. 1978;190:905–926
  131. De Rooij DG, Lok D. Regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogonia. Anat Rec. 1987;217:131–136
  132. Hikim AP, Wang C, Leung A, et al. Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment. Endocrinology. 1995;136:2770–2775
  133. Troiano L, Fustini MF, Lovato E, et al. Apoptosis and spermatogenesis: evidence from an in vivo model of testosterone withdrawal in the adult rat. Biochem Biophys Res Commun. 1994;202:1315–1321
  134. Gendrel D, Roger M, Job JC. Plasma gonadotropin and testosterone values in infants with cryptorchidism. J Pediatr. 1980;97:217–220
  135. Lee PA. Fertility in cryptorchidism. Does treatment make a difference?. Endocrinol Metab Clin North Am. 1993;22:479–490
  136. Puri P, O'Donnell B. Semen analysis of patients who had orchidopexy at or after seven years of age. Lancet. 1988;2:1051–1052
  137. Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data. Horm Res. 2001;55:28–32
  138. Lee PA, O'Leary LA, Songer NJ, et al. Paternity after bilateral cryptorchidism. A controlled study. Arch Pediatr Adolesc Med. 1997;151:260–263
  139. Taskinen S, Hovatta O, Wikstrom S. Early treatment of cryptorchidism, semen quality and testicular endocrinology. J Urol. 1996;156:82–84
  140. Gracia JJ, Sánchez Zalabardo J, Sánchez García J, et al. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. BJU Int. 2000;85:1100–1103
  141. Miller KD, Coughlin MT, Lee PA. Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters. Horm Res. 2001;55:249–253
  142. Lee PA, Coughlin MT, Bellinger MF. Inhibin B: comparison with indexes of fertility among formerly cryptorchid and control men. J Clin Endocrinol Metab. 2001;86:2576–2584
  143. Coughlin MT, Bellinger MF, Lee PA. Age at unilateral orchiopexy. Effect on hormone levels and sperm count in adulthood. J Urol. 1999;162:986–988
  144. United Kingdom Testicular Cancer Study Group. Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. BMJ. 1994;308:1393–1399
  145. Carmona Campos E, Regueiro Lopez JC, Prieto Castro R, et al. Cryptorchism and testicular cancer. Actas Urol Esp. 2000;24:49–51
  146. Stone JM, Cruickshank DG, Sandeman TF, et al. Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia. Br J Cancer. 1991;64:132–138
  147. Haughey BP, Graham S, Brasure J, et al. The epidemiology of testicular cancer in upstate New York. Am J Epidemiol. 1989;130:25–36
  148. Deming CL. The evolution of hormonal therapy in cryptorchidism. J Urol. 1952;68:354–357
  149. Hadziselimovic F, Girard J, Herzog B. 4 years' experience with combined hormonal treatment of cryptorchism. Z Kinderchir. 1984;9:324–327
  150. Hadziselimovic F, Senn E, Bandhauer K. Effect of treatment with chronic gonadotropin releasing hormone agonist on human testis. J Urol. 1987;138:1048–1050
  151. Job JC, Canlorbe P, Garagorri JM, et al. Hormonal therapy of cryptorchidism with human chorionic gonadotropin (HCG). Urol Clin North Am. 1982;9:405–411
  152. Rajfer J, Handelsman DJ, Swerdloff RS, et al. Hormonal therapy of cryptorchidism. A randomized, double-blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone. N Engl J Med. 1986;314:466–470
  153. deMuinck Keizer-Schrama SM, Hazebroek FW, Matroos AW, et al. Double-blind, placebo-controlled study of luteinising-hormone-releasing-hormone nasal spray in treatment of undescended testes. Lancet. 1986;1:876–880
  154. Cortes D, Thorup J, Visfeldt J. Hormonal treatment may harm the germ cells in 1–3-year-old boys with cryptorchidism. J Urol. 2000;163:1290–1292
  155. Dunkel L, Taskinen S, Hovatta O, et al. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest. 1997;100:2341–2346
  156. Cortes D, Thorup JM, Visfeldt J. Cryptorchidism. Aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism. Horm Res. 2001;55:21–27
  157. Swerdlow AJ, Higgins CD, Pike MC. Risk of testicular cancer in cohort of boys with cryptorchidism. BMJ. 1997;314:1507–1511
  158. Pereira Arias JG, Astobieta Odriozola A, Zabalza Estevez I, et al. Cryptorchidism and testicular Cancer. Arch Esp Urol. 1995;48:959–961
  159. Jones BJ, Thornhill JA, O'Donnell B, et al. Influence of prior orchiopexy on stage and prognosis of testicular cancer. Eur Urol. 1991;19:201–203
  160. Docimo SG, Silver RI, Cromie W. The undescended testicle: diagnosis and management. Am Fam Physician. 2000;62:2047–2048
  161. Rogers E, Teahan S, Gallagher H, et al. The role of orchiectomy in the management of postpubertal cryptorchidism. J Urol. 1998;1159:851–854

PII: S1477-5131(04)00003-8

doi: 10.1016/j.jpurol.2004.11.001

Journal of Pediatric Urology
Volume 1, Issue 1 , Pages 11-25 , February 2005

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